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Application of a traditional Chinese medicine composition for nourishing the kidney and strengthening the bones in the preparation of medicines for the treatment of bone and joint pain caused by aromatase inhibitors

A composition and technology for bone and joint symptoms, applied in drug combinations, non-central analgesics, medical preparations containing active ingredients, etc., to achieve the effects of alleviating pain, improving hand and joint pain, and improving joint pain

Inactive Publication Date: 2019-01-04
BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the pathogenesis and treatment of AIMSS are still in the stage of research and exploration. Due to the lack of effective intervention measures, AIMSS will be a major hidden danger for the termination of endocrine therapy and tumor recurrence.

Method used

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  • Application of a traditional Chinese medicine composition for nourishing the kidney and strengthening the bones in the preparation of medicines for the treatment of bone and joint pain caused by aromatase inhibitors
  • Application of a traditional Chinese medicine composition for nourishing the kidney and strengthening the bones in the preparation of medicines for the treatment of bone and joint pain caused by aromatase inhibitors
  • Application of a traditional Chinese medicine composition for nourishing the kidney and strengthening the bones in the preparation of medicines for the treatment of bone and joint pain caused by aromatase inhibitors

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] Experimental Example 1: Effect of Yishen Jiangu Granules on Bone and Joint Symptoms Related to Breast Cancer Aromatase Inhibitors

[0030] 1. Research methods

[0031] 1.1 Research design: multi-center, randomized, double-blind, placebo-controlled clinical research.

[0032] 1.1.1 Research Center

[0033] All the cases were completed in the Oncology Department of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, the Department of Integrated Traditional Chinese and Western Medicine of Beijing Cancer Hospital, and the outpatient and ward of Guang'anmen Hospital of China Academy of Chinese Medical Sciences.

[0034] 1.1.2 Stochastic method

[0035] In this study, block random method was used.

[0036] 1.1.3 Blind design

[0037] This study adopted a double-blind design.

[0038] 1.1.4 Control settings

[0039] Inter-group comparison between the traditional Chinese medicine group and the control group; self-control before and a...

Embodiment 1

[0100] 1. Prescription:

[0101] Rehmannia glutinosa 200g, cornus 150g, dodder 100g, achyranthes bidentata 150 parts, Cyperus cyperi 100g, angelica 100g, poria cocos 150g, white peony root 150g, chuanxiong 100g, corydalis 150g, sarcocarpus 150g, tectonicus 200g.

[0102] 2. Preparation method:

[0103] Decoct the medicinal flavor with water twice, the first time for 60 minutes, the second time for 30 minutes, filter, concentrate, add appropriate amount of auxiliary materials, mix well, dry, and granulate to obtain.

Embodiment 2

[0105] 1. Prescription:

[0106] Rehmannia glutinosa 190g, Cornus 170g, Dodder 110g, Achyranthes sichuanensis 120g, Rhizoma Cyperi 130g, Angelica 120g, Poria cocos 170g, Radix Paeoniae Alba 130g, Rhizoma Chuanxiong 120g, Corydalis 130g, Speranthum 160g, Spermus 190g.

[0107] 2. Preparation method:

[0108] Decoct the medicinal flavor with water twice, the first time for 60 minutes, the second time for 30 minutes, filter, concentrate, add appropriate amount of auxiliary materials, mix well, dry, and granulate to obtain.

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Abstract

The invention discloses application of a kidney-tonifying bone-fortifying traditional Chinese medicine composition to prepare medicines treating bone joint pain caused by an aromatase inhibitor. The bulk drugs of the traditional Chinese medicine composition comprise, in parts by weight, 150-250 parts of radix rehmanniae preparata, 100-200 parts of fructus corni, 60-150 g of semen cuscutae, 100-200 parts of radix cyathulae, 70-160 parts of rhizoma cyperi, 70-150 parts of radix angelicae sinensis, 100-200 parts of poria, 100-200 parts of radix paeoniae alba, 60-150 parts of rhizoma chuanxiong, 100-200 parts of rhizoma corydalis, 100-200 parts of herb of tuberculate speranskia, and 150-250 parts of caulis trachelospermi. Through clinic test research, the traditional Chinese medicine composition is discovered to be capable of treating ache, bone arthritis, hand rheumatoid arthritis caused by the aromatase inhibitor.

Description

technical field [0001] The present invention relates to a new application of a traditional Chinese medicine composition for nourishing the kidney and strengthening bones, in particular to the application of the traditional Chinese medicine composition for nourishing the kidney and strengthening bones in the preparation of medicines for treating bone and joint pain caused by aromatase inhibitors. Background technique [0002] Breast cancer is the most common type of female malignancy and the leading cause of death. According to the GLOBOCAN 2012 estimate released by the International Cancer Research Center of the World Health Organization, in 2012, there were approximately 1.7 million newly diagnosed cases of breast cancer in women worldwide, and 522,000 deaths. In China, breast cancer ranks first among female cancers, with approximately 210,000 new cases each year and a mortality rate of 8.65 / 100,000, ranking sixth among female cancer deaths. At present, the treatment of br...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61P19/02A61P19/08A61P29/00
Inventor 王笑民杨国旺郁仁存于明薇彭楠
Owner BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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