Instrument for determination of adhesive force and application thereof

Abstract

The invention discloses an instrument including an upper insert panel (10), a lower insert panel (11), a container (6), a fixed pulley (8), a connection belt, a dripping device, a controller (3), a baffle plate (7) and a pressure sensor (9). The invention also provides an application of the instrument in determination of adhesive force and a method for determination of the adhesive force. The standardized instrument for determination of the adhesive force is automatic to operate and rapid in response, can precisely control the experiment temperature, is quite suitable for determination of the adhesive force, and not only avoids the error generated by manual operation, but also makes different test data have comparability; and the determination method is simple, is accurate in results, and is quite beneficial for application in industries.

Description

technical field [0001] The invention relates to an instrument for measuring adhesion force and its application, in particular to an instrument for measuring the adhesion force of temperature-sensitive in-situ gel and its application. Background technique [0002] In situ gel (insituge1), also known as in situ gel, can be divided into temperature-sensitive, pH-sensitive, ion-sensitive, light-sensitive, etc. Among them, the research on temperature-sensitive in situ gel is the most mature and is widely used Widely used in the field of pharmacy, for example: as a drug carrier, etc. [0003] When the temperature-sensitive gel is used in the vagina, eyes, nasal cavity, oral cavity and other cavity or mucous membranes, bioadhesion is an important indicator. , the drug can achieve the expected release effect. Therefore, the determination of bioadhesion is very necessary. [0004] At present, a simple self-made device is usually used in this field to measure the bioadhesion force:...

AI Technical Summary

Problems solved by technology

[0006] (1) There is a large difference between self-made devices, and the adhesion results measured by different self-made devices are generally not comparable;

[0007] (2) All manual operation has large errors, especially in the process of injecting liquid, not only it is not easy to control the uniform inflow of liquid, but also it is difficult to accurately judge the time point to stop adding liquid;

[0008] (3) The container is open. When the upper and lower plates are separated, the liquid is likely to spill due to the weightlessness of the container, resulting in inaccurate measurement results of the adhesion force;

[0009] (4) Temperature control cannot be realized, and it is difficult to accurately measure the adhesion force when the sample to be tested is sensitive to temperature;

[0010] (5) It is not easy to fix the biological mucous membrane on the upper and lower plates. During the measurement process, the mucous membrane may fall off from the upper and lower plates, which is not conducive to the determination of adhesion force, which is time-consuming and laborious.

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