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A method for selective extraction and separation of curcumin

A separation method and technology of curcumin, which is applied in the field of separation and purification, can solve the problems of less separation methods and difficult separation and purification of curcumin monomer, and achieve the effects of low price, simple operation and simple process

Active Publication Date: 2017-03-08
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] At present, because curcumin monomer is not easy to separate and purify, and there are few separation methods reported, people mainly extract mixed pigments from turmeric, so curcumin, demethoxycurcumin and bisdemethoxy curcumin are usually sold on the market. Mixture of curcuminoids, referred to as crude curcuminoids

Method used

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  • A method for selective extraction and separation of curcumin
  • A method for selective extraction and separation of curcumin
  • A method for selective extraction and separation of curcumin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 8 mL of crude curcumin dissolved in 1,2-dichloroethane, and then mix it with 0.1 mol / L, pH=3 aqueous solution of hydroxypropyl-β-cyclodextrin and 0.1 mol / L Na 2 HPO 4 The solutions were mixed in equal volumes, shaken at a constant temperature of 20°C for 5 h, left to stand, and the contents of the three in the cyclodextrin solution were analyzed by HPLC. The distribution ratios of curcumin, demethoxycurcumin and bisdemethoxycurcumin in cyclodextrin solution and organic phase were 1.255, 0.066 and 0.006, respectively. Flowchart such as figure 1 shown.

Embodiment 2

[0028] Take 8 mL of crude curcumin dissolved in dichloromethane, and then mix it with 0.1 mol / L, pH=4 aqueous solution of hydroxypropyl-β-cyclodextrin and 0.1 mol / L Na 2 HPO 4 The solutions were mixed in equal volumes, shaken at a constant temperature of 5°C for 5 h, left to stand, and the contents of the three in the cyclodextrin solution were analyzed by HPLC. The distribution ratios of curcumin, demethoxycurcumin and bisdemethoxycurcumin in cyclodextrin solution and organic phase were 2.269, 0.101 and 0.007, respectively.

Embodiment 3

[0030] Take 8 mL of crude curcumin dissolved in dichloromethane, and then mix it with 0.05 mol / L, pH=3 aqueous solution of hydroxypropyl-β-cyclodextrin and 0.1 mol / L Na 2 HPO 4 The solutions were mixed in equal volumes, shaken at a constant temperature of 30°C for 5 h, left to stand, and the contents of the three in the cyclodextrin solution were analyzed by HPLC. The distribution ratios of curcumin, demethoxycurcumin and bisdemethoxycurcumin in cyclodextrin solution and organic phase were 0.833, 0.031 and 0.005, respectively.

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Abstract

The invention discloses a method for selectively extracting and separating curcumin. According to the method, an industrial product-curcumin crude product is used as a raw material, and a curcumin-demethoxycurcumin-bisdemethoxycurcumin mixture and hydroxypropyl-beta-cyclodextrin are used as extractants. The method comprises the following steps: mixing a curcumin-demethoxycurcumin-bisdemethoxycurcumin mixture solution dissolved by using a water-insoluble organic solvent 1,2-dichloroethane or dichloromethane with a 0.05-0.2 mol / L hydroxypropyl-beta-cyclodextrin water solution with the pH value of 2-7 and the Na2HPO4 concentration of 0.1 mol / L in an isometric mode, oscillating at the constant temperature of 15-40 DEG C for 5 hours, standing so that the curcumin, demethoxycurcumin and bisdemethoxycurcumin are selectively extracted into the hydroxypropyl-beta-cyclodextrin water solution, and extracting the curcumin of the hydroxypropyl-beta-cyclodextrin water solution with ethyl acetate. The method has the advantages of simple technique, cheap raw material and favorable separating effect.

Description

technical field [0001] The invention belongs to the field of separation and purification, and in particular relates to a method for selectively extracting and separating curcumin. Background technique [0002] Curcumin is a general term for a slightly acidic yellow phenolic substance extracted from the rhizome of Curcuma longa, a plant of the genus Curcuma longa. Curcumin is a natural pigment with stable color and low toxicity. It can be used as a colorant for some foods, and Strong coloring power, widely used in food additives and fuels. It has antibacterial, antiviral, antioxidative, hepatoprotective, choleretic, hypolipidemic, anticancer, and anti-HIV effects, and has good clinical application value and research and development potential. Its main components include curcumin (CurⅠ), demethoxycurcumin (CurⅡ) and bisdemethoxycurcumin (CurⅢ). Its structural formula is as follows respectively: [0003] [0004] curcumin [0005] [0006] Demethoxycurcumin [0007] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/80C07C49/255
CPCC07C45/80C07C49/255
Inventor 纪红兵吴梅香柴坤刚秦祖赠
Owner SUN YAT SEN UNIV
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