Method for preparing throat coughing atomization inhalation powder

Abstract

The invention discloses a method for preparing throat coughing atomization inhalation powder to solve the problem of laryngeal cough treatment. The method is characterized by comprising the following steps: (1) extracting volatile oils from pawpaws, wintercreeper, ailanthus altissima swingle, pseudodrynaria coronans, semen aesculi, cinnamomum camphora, solanum lyratum thunb, semen lini and resina liquidambaris coarse powder to obtain mixed volatile oil and medicinal dregs for later use; (2) uniformly mixing pyrola rotundifolia, tricyrtis root and semen euryales with the medicinal dregs obtained in the step (1), performing water extraction and alcohol precipitation, filtering to remove alcohol, performing ultrafiltration by a microporous membrane, concentrating and drying the filtrate to obtain a primary material; and (3) spraying the volatile oil obtained in the step (1) into the primary material obtained in the step (2), uniformly mixing, grinding, screening by a 100-mesh screen, and sterilizing. Clinical experiments prove that the throat coughing atomization inhalation powder has the characteristics of good curative effect and relatively high safety when being used for treating laryngeal cough, and is worthy of clinical application and popularization.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for preparing throat cough atomized inhalation powder. Background technique [0002] Laryngogenic cough, referred to as laryngeal cough, refers to the cough caused by throat lesions. The clinical features are: various coughing causes, some cough due to dry throat, some cough due to itchy throat, some cough due to inhalation of cold air, some cough due to talking, it is paroxysmal cough, and it is intermittent at first , develop into persistent cough over time, recurrent attacks. Its pathogenesis lies in: hyperplasia of lymphoid follicles on the posterior pharyngeal wall of the throat, or accompanied by blockage of mucous glands under the laryngeal mucosa, mucus retention, various factors cause hypersensitivity of the nerves in the throat, and pathological enhancement of cough reflex. Anti-inflammatory treatment is mostly used in clinical treatment, but the ...

AI Technical Summary

Problems solved by technology

Anti-inflammatory treatment is mostly used in clinical treatment, but the effect of antibiotics is not good, it can only play a little relief, and it is very stubborn, which brings great pain to patients

[0003] Therefore, at present, the treatment of throat cough mainly relies on traditional Chinese medicine. The pathogenesis of existing traditional Chinese medicine is mostly based on the invasion of exogenous pathogens and the deficiency of viscera. However, in fact, some patients with throat cough are not simply "dry cough". Dry throat, itchy throat, cold air, talking, etc. can cause cough, and some pathology shows that it is caused by mucus retention under the laryngeal mucosa. Because blindly "clearing fire and moistening dryness" can't get good results

The use of antitussive drugs can sometimes reduce the cough reflex through the central antitussive effect in a short period of time, and achieve the purpose of antitussive, but patients often have recurrent attacks within one to two weeks, because the mucosal lesions of the posterior pharyngeal wall have not improved. After the effect of antitussive drugs wears off, the cough reflex returns and the symptoms come back

Especially for pediatric patients, the cough reflex cannot be controlled, and mild throat discomfort can induce cough, and for pediatric patients, there are contraindications to the use of antitussive drugs

[0004] At present, aerosol inhalation is also used in clinical treatment, but the current aerosol inhalation drugs are mainly aimed at the lower respiratory tract. For the mucous membrane of the throat, the local drug effect is not good due to the poor adhesion of the aerosol inhalation drug, but the use of mucosal adhesion Excipients may enhance throat mucous membrane irritation and enhance cough