Continuous sterilization and repetition learning self-adaptive controller on the basis of characteristic model

Abstract

The present invention provides a continuous sterilization and repetition learning self-adaptive controller on the basis of characteristic model including a characteristic model identifying module, an overall coefficient control law module, a repetition learning feed-forward module, and an overhead control quantity calculating module. The characteristic model identifying module acquires the temperature of the culture medium at the current steam ejector outlet and the steam valve opening so as to obtain identifying parameters, and the overall coefficient control law module receives the identifying parameters and the error of the temperature of the culture medium and the reference temperature so as to obtain the feedback control quality. The repetition learning feed-forward module constructs and updates a feedback lookup table. The overhead controlled quantity calculating module obtains the current steam valve opening according to the feedback control quality and the feed-forward control quality. The continuous sterilization and repetition learning self-adaptive controller on the basis of characteristic model constantly optimizes the lookup table by repetition learning so that the turbulence of measurable fast variables, such as material inlet temperature and material flow, can be eliminated, and the influence of the measurable fast variables during the continuous sterilization process can be reduced. The continuous sterilization and repetition learning self-adaptive controller on the basis of characteristic model is strong in robustness and is simple in realization.

Description

technical field [0001] The invention relates to a controller of a continuous sterilization automatic control system in the production process of biopharmaceuticals, and belongs to the technical field of biological control, in particular to a continuous sterilization repeated learning self-adaptive controller based on a feature model. Background technique [0002] The continuous sterilization automatic control system in the production process of biopharmaceuticals is a continuous sterilization (referred to as continuous sterilization, the same below) equipment used in biological fermentation engineering, which can automatically realize the heating, heat preservation and cooling of the medium, and achieve sterilization in a short time The purpose of killing useless bacteria. At present, the automatic continuous sterilization process has become one of the new technologies urgently needed by bio-fermentation enterprises, and it is also the main development trend of sterilization...

AI Technical Summary

Problems solved by technology

[0003] At present, the PID controllers or controllers based on fuzzy logic commonly used in industrial control generally have the characteristics that it is difficult to adjust adaptively according to the production conditions. Once the control parameter

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