The invention discloses a method for conducting rapid initial alignment on vehicle load inertial navigation motion based on auto-disturbance-rejection control.The method is characterized by comprising the following steps that 1, before a vehicle is started, inertial navigation is initialized, and coarse alignment under the condition of an inertial navigation static base is completed; 2, after the vehicle is started, the observation quantity is constructed through inertial navigation and velocity information output by a mileometer; 3, a motion fine alignment loop is designed through the observation quantity, an inertial navigation error equation and an auto-disturbance-rejection control method; 4, parameters of an auto-disturbance-rejection controller are adjusted and finalized; 5, a feedback matrix is constructed through the misalignment angle output by an observer, so that initial alignment of vehicle load inertial navigation motion is achieved.By means of the steps, the coarse alignment method, observation quantity construction, the design method of the auto-disturbance-rejection control loop and the like adopted before the loaded vehicle is started are described in details; by means of the method, statistics characteristics of noise do not need to be known in advance, a quite precise model is not needed either, and the rapid inertial navigation alignment problem under the vehicle load environment and the problem of compensation under the external disturbance in the vehicle load process of inertial navigation can be solved.