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Nano-gold-based targeted non-homogeneous biological tissue photo-thermal therapy modeling method

A biological tissue and non-homogeneous technology, applied in the field of biomedical photonics, can solve the problems of simple models, complex biological living bodies, and the inability to target nano-gold to live animal photothermal therapy experimental theoretical guidance, etc., to achieve a solution Effects of Quantitative Questions

Inactive Publication Date: 2016-01-27
屈晓超
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Problems solved by technology

[0005] To sum up, for the modeling of nano-gold targeting biological tissue photothermal therapy, the existing research is based on homogeneous biological tissue, and the model is too simple, far from the complex living body, and it is impossible to realize the modeling of nano-gold. Effective theoretical guidance for photothermal therapy experiments targeting living animals

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  • Nano-gold-based targeted non-homogeneous biological tissue photo-thermal therapy modeling method

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Embodiment Construction

[0027] The present invention will be further described below with reference to the accompanying drawings.

[0028] refer to figure 1 , the concrete steps of the present invention are as follows:

[0029] (1) Collection of heterogeneous biological tissue data

[0030] The small living animal is fixed on the rotating table of the CT imaging system, and the area of ​​interest of the small living animal is irradiated with X-rays from no less than 360 angles, and the CT projection data of multiple angles are collected by the X-ray detector. Reconstruction of heterogeneous biological tissue using CT.

[0031] The acquisition of multi-angle CT projection data, control the imaging body to rotate at equal intervals to a certain small angle, generally not more than 1 0 (select 1 in this example 0 ) to collect projection data from no less than 360 angles (360 angles in this example).

[0032] (2) Obtaining the anatomical structure of heterogeneous biological tissue

[0033] The hum...

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Abstract

The invention discloses a nano-gold-based targeted non-homogeneous biological tissue photo-thermal therapy modeling method and solves the problem that heat absorbed by a lesion part cannot be analyzed quantitatively when nano-gold photo-thermal therapy is carried out on the biological tissue in the prior art. The method describes an optical transmission process in the biological tissue according to the Boltzmann radiation transmission equation diffusion theory, and establishes a photo-thermal model of the nano-gold-based targeted non-homogeneous biological tissue according to a Pennes biological heat transfer equation and based on a thermal diffusion theory with heat conduction being a main approach. The method comprises the following steps: establishing a nano-gold-based targeted non-homogeneous biological tissue model; obtaining nano-gold-based targeted non-homogeneous biological tissue model data; establishing a light source model; establishing an optical transmission model; and establishing a heat transmission model. Under the condition of knowing the laser radiation power value and nanogold concentration value, light and heat absorbed by the lesion part after being injected with nanogold can be calculated, thereby optimizing treatment parameter so as to enhance photothermal conversion capability of the target area, and improving photo-thermal treatment efficiency of a living body.

Description

technical field [0001] The invention belongs to the technical field of biomedical photonics, and further relates to a method for establishing light transmission and thermal diffusion models in the interaction of light and nano-gold targeted biological tissue. This method can be used to guide the quantification of photothermal therapy parameters and the optimization of their positions in clinical applications such as photothermal therapy and laser dynamic therapy of tumors. Background technique [0002] Gold nanoparticles-based tumor photothermal therapy can precisely locate and target tumor tissue, and has great potential to improve treatment efficiency, reduce side effects and improve quality of life. A review article published in the journal NatureReviewsCancer in 2012 SchroederA, HellerDA, WinslowMM, et al. The unique properties of controlled surface chemistry, suitable size structure and potential low toxicity play an important role in tumor therapy and have the advanta...

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Application Information

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IPC IPC(8): A61N5/067A61N5/06
Inventor 屈晓超鱼迎珍石阳
Owner 屈晓超
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