Method for determining specific migration quantity of nine kinds of antioxidants in plastic product through liquid chromatography-mass spectrometry method

Abstract

The invention provides a method for determining the specific migration quantity of nine kinds of antioxidants in a plastic product through a liquid chromatography-mass spectrometry method. Through the method, the specific total migration quantity of nine kinds of antioxidants in five kinds of food simulants can be determined. The method includes the steps that a sample to be measured is soaked in the food simulants, the sample to be measured and the food simulants are cooled to room temperature and evenly mixed, and after the food simulants are diluted and filtered through a hydrophilic teflon syringe filter, sample introduction is performed; after the olive oil food simulants are extracted through methanol n-heptane and filtered through the hydrophilic teflon syringe filter, sample introduction is performed; gradient elution separation is performed through a C8 column; an electrospray ionization source is adopted for mass spectrometry and operates in a negative ion multi-reaction monitoring mode. According to the method, chromatographic separation and a linear relation are good, the recovery rate and the accuracy are high, the limit of quantitation meets limit requirements of nine kinds of antioxidants in the EU NO 10 / 2011 regulation, and the method has been applied to detecting practical samples.

Description

technical field [0001] The invention belongs to the field of chemical detection, and relates to a detection method for the specific migration of 9 kinds of harmful antioxidants in food contact materials, in particular to a high-performance liquid chromatography tandem mass spectrometry (HPLC-MS / MS) method for the determination of plastic food packaging Methods for specific migration of 9 antioxidants in materials and containers. Background technique [0002] Plastic food contact materials often need to add functional additives such as antioxidants and ultraviolet absorbers to prolong the service life of related products. However, during the use of the product, these added antioxidants will also migrate into the food, directly endangering human health. The (EU) NO10 / 2011 regulation issued by the European Union in 2011 limits the specific migration amount (SML) or specific total migration amount [SML(T)] of various antioxidants. [0003] At present, the detection of antioxid...

AI Technical Summary

Problems solved by technology

Existing literature on the detection of antioxidants in food simulants can only detect the SML of several antioxidants in food simulants, because the types of antioxidants detected at the same time are not the same as those listed in Schedule 2 of EU (EU) NO10 / 2011 regulations The types of the 9 antioxidants are not completely consistent, and the specific total migration of the 9 antioxidants in the EU (EU) NO10 / 2011 regulations cannot be detected

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