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A kind of t1-t2 dual-mode mri contrast agent and its preparation method and application

A T1-T2, contrast agent technology, applied in the direction of MRI/MRI contrast agent, emulsion delivery, drug delivery, etc., can solve the problems of unsatisfactory medical detection, low relaxation efficiency, low detection sensitivity, etc., to achieve Easy to promote, simple synthesis conditions, and enhanced contrast effect

Inactive Publication Date: 2018-10-23
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Single-mode T1 and T2 weighted MR imaging, due to its low relaxation efficiency and low detection sensitivity, cannot meet the requirements of medical detection.

Method used

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  • A kind of t1-t2 dual-mode mri contrast agent and its preparation method and application
  • A kind of t1-t2 dual-mode mri contrast agent and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A specific implementation of the contrast agent of the present invention is specifically completed through the following process:

[0028] 23.1g FeCl 3 ·6H 2 0, 11.6g FeCl 2 ·4H 2 0 Respectively dissolve in a certain amount of deionized water, and then place it in a 250mL four-neck flask equipped with a reflux condenser, N 2 Under air protection, stir quickly in a constant temperature water bath at 40°C for 10 minutes, and slowly add 70 mL of ammonia water dropwise to pH = 10, forming a black precipitate. Stirring is continued, and the temperature is raised to 70°C to react for 1 hour, cooled to room temperature, washed with deionized water to neutrality, and magnetically separated for use.

[0029] Disperse the prepared ferroferric oxide nanoparticles in a mixed solvent of 50 mL water and 50 mL absolute ethanol, control the temperature in a water bath at 80°C, add 4 g of oleic acid, react for 1 hour and then cool to room temperature, magnetically separate the product, and us...

Embodiment 2

[0032] Another specific implementation of the contrast agent of the present invention is specifically completed through the following process:

[0033] 23.1g FeCl 3 ·6H 2 0, 11.6g FeCl 2 ·4H 2 0 Respectively dissolve in a certain amount of deionized water, and then place it in a 250mL four-neck flask equipped with a reflux condenser, N 2 Under air protection, stir quickly in a constant temperature water bath at 40°C for 10 minutes, and slowly add 70 mL of ammonia water dropwise to pH = 10, forming a black precipitate. Stirring is continued, and the temperature is raised to 70°C to react for 1 hour, cooled to room temperature, washed with deionized water to neutrality, and magnetically separated for use.

[0034] Disperse the prepared ferroferric oxide nanoparticles in a mixed solvent of 50 mL water and 50 mL absolute ethanol, control the temperature in a water bath at 80°C, add 4 g of oleic acid, react for 1 hour and then cool to room temperature, magnetically separate the product, ...

Embodiment 3

[0039] Another specific implementation of the contrast agent of the present invention is specifically completed through the following process:

[0040] 23.1g FeCl 3 ·6H 2 0, 11.6g FeCl 2 ·4H 2 0 Respectively dissolve in a certain amount of deionized water, and then place it in a 250mL four-neck flask equipped with a reflux condenser, N 2 Under air protection, stir quickly in a constant temperature water bath at 40°C for 10 minutes, and slowly add 70 mL of ammonia water dropwise to pH = 10, forming a black precipitate. Stirring is continued, and the temperature is raised to 70°C to react for 1 hour, cooled to room temperature, washed with deionized water to neutrality, and magnetically separated for use.

[0041] Disperse the prepared ferroferric oxide nanoparticles in a mixed solvent of 50 mL water and 50 mL absolute ethanol, control the temperature in a water bath at 80°C, add 4 g of oleic acid, react for 1 hour and then cool to room temperature, magnetically separate the product, ...

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Abstract

The invention discloses a T1-T2 dual-mode MRI contrast medium and a preparation method and application thereof. The contrast medium is of a core-shell structure and is specifically prepared from Fe3O4 nano particles serving as a core and a styrene, glycidyl methacrylate and functional rare-earth-containing gadolinium (III) complex Gd(AA)3Phen serving as a shell. The contrast medium prepared through a seed emulsifier-free emulsion polymerization method has both the T1 imaging function and the T2 imaging function. The preparation method is simple, environmentally friendly and low in cost, and the obtained product is excellent in performance and has great potential application value in cancer or tumor diagnosis and treatment.

Description

Technical field [0001] The invention relates to the field of materials science and biomedicine technology, in particular to a T1-T2 bimodal MRI contrast agent and its preparation method and application. Background technique [0002] Magnetic resonance imaging (MRI) has become one of the most powerful detection methods in contemporary clinical diagnosis due to its high resolution, no ionizing radiation damage, multi-parameter, multi-sequence imaging and other advantages. In order to highlight the differences between tissues, especially the differences between normal tissues and patient parts, an effective way to improve imaging contrast is to use contrast agents. According to the principle of action, MRI contrast agents can be divided into longitudinal relaxation contrast agents (T1 preparations) and transverse relaxation contrast agents (T2 preparations). [0003] In order to meet the high requirements of modern medical treatment for diagnostic accuracy, the diagnostic combination...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K49/18
Inventor 徐祖顺张力梁爽刘瑞清廖光福
Owner HUBEI UNIV
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