Preparation methods of hydroxypropyl methyl cellulose-soybean protein copolymer and its plant capsule

A technology of hydroxypropyl methylcellulose and soybean protein, which is applied in the direction of capsule delivery and non-active ingredients of polymer compounds, can solve the problems of not being widely used, high cost, and slow gelation speed, etc., and achieve a solution The effect of high production costs

Active Publication Date: 2016-02-03
TAIAN RUITAI CELLULOSE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, cellulose derivatives also show great development potential and have been successfully industrialized. Although HPMC capsules have similar solubility, disintegration and bioavailability to gelatin capsules, they also have some advantages that gelatin capsules do not have. However, the current application is still not very wide
The main reason is that the breakage rate and price of the finished capsule are too high. Compared with gelatin, the raw material cost of HPMC is higher; in addition, the gelation speed of HPMC is slow, resulting in long production cycle and high energy consumption

Method used

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  • Preparation methods of hydroxypropyl methyl cellulose-soybean protein copolymer and its plant capsule
  • Preparation methods of hydroxypropyl methyl cellulose-soybean protein copolymer and its plant capsule
  • Preparation methods of hydroxypropyl methyl cellulose-soybean protein copolymer and its plant capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Dissolve 10g of hypromellose succinate (degree of acylation: 12.5), 10g of soybean protein isolate, and 1.0g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in 100mL deionized water, then add 0.5g 4-dimethylaminopyridine, stir and react at room temperature overnight; after concentrating the reaction solution under reduced pressure, add an appropriate amount of ethyl acetate to precipitate the product, wash and filter the product, and vacuum dry to obtain the target product. 91%.

Embodiment 2

[0031] Dissolve 5g of hypromellose succinate (degree of acylation: 12.5), 10g of soybean protein isolate, and 1.0g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in 100mL deionized water, then add 0.5g 4-dimethylaminopyridine, stir and react at room temperature overnight; after concentrating the reaction solution under reduced pressure, add an appropriate amount of ethyl acetate to precipitate the product, wash and filter the product, and vacuum dry to obtain the target product. 92%.

Embodiment 3

[0033] Dissolve 10g of hypromellose succinate (degree of acylation: 18.3), 10g of soybean protein isolate, and 1.0g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in 100mL of deionized water, then add 0.5g of N-hydroxysuccinimide, and stir at room temperature overnight; after concentrating the reaction solution under reduced pressure, add an appropriate amount of ethyl acetate to precipitate the product, wash and filter the product, and vacuum dry to obtain the target product. The rate is 95%.

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PUM

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Abstract

The invention discloses preparation methods of a hydroxypropyl methyl cellulose-soybean protein copolymer and its plant capsule, and belongs to the technical field of chemical synthesis and medical accessory materials. The preparation method of the hydroxypropyl methyl cellulose-soybean protein copolymer orderly comprises 1, adding a hydroxypropyl methyl cellulose derivative, soybean protein, a catalyst and a reaction medium into a reaction container and carrying out stirring heating for polymerization, and 2, after the reaction, cooling the reaction product to the room temperature, adding a precipitating agent into the concentrated reaction liquid, carrying out filtration and washing, and drying the precipitates to obtain the hydroxypropyl methyl cellulose-soybean protein copolymer. The preparation method of the plant capsule prepared from the hydroxypropyl methyl cellulose-soybean protein copolymer as a main raw material utilizes a dip-coating method and can solve the problem that the existing plant capsule preparation method has a high production cost, complex processes, unstable quality standards and uncontrollable quality.

Description

technical field [0001] The invention relates to a preparation method of hydroxypropyl methylcellulose copolymer and plant capsule thereof, and belongs to the technical field of chemical synthesis and medical auxiliary materials. Background technique [0002] Capsules (Capsules) have many advantages such as masking the taste of drugs, high drug efficacy, controlled and sustained release, etc., and are widely used in medicines, health products and functional foods. So far, they have a history of more than 160 years of application. At present, capsule products on the market are basically prepared from gelatin (Gelatin). Gelatin is produced by hydrolysis of animal bones and skins. It is a biomacromolecule with a three-dimensional helical structure and has good biocompatibility and physical and chemical properties. The unique structural characteristics of gelatin molecules make it difficult to overcome shortcomings in application, for example, it is easy to cross-link with dru...

Claims

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Application Information

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IPC IPC(8): C08G81/00A61K47/42A61K9/48
Inventor 唐汝培吕兴富孙建刚
Owner TAIAN RUITAI CELLULOSE
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