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Weiyankang capsules and preparation method thereof

A technology of capsules and pantothenic acid, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., and can solve the problems of slow disintegration, unsatisfactory curative effect, and low curative effect

Inactive Publication Date: 2016-02-24
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of Weiyankang Capsules on the market is not ideal due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Weiyankang capsules and preparation method thereof
  • Weiyankang capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 11.2g of Styrax, 56g of Gansong, 48g of Digupi, 120g of Radix Paeoniae Alba, 72g of Radix Glycyrrhizae, and 56g of Guizhi, grind them into 60-mesh coarse powder, use carbon dioxide supercritical extraction method to extract, extraction pressure is 16Mpa, extraction temperature is 16°C, separate The pressure of the separator is 12Mpa, the temperature of the separator is 37°C, the separation time is 2.8 hours, and the flow rate of carbon dioxide is 21L per hour to obtain the extract; take the extract and dry it under reduced pressure at 63°C to obtain a dry paste; take the dry paste and add 150g of mannitol, and use high-energy nano impact Grind and pulverize into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 45g of microcrystalline cellulose, 45g of cross-linked polyvinylpyrrolidone, and 35g of cross-linked sodium carboxymethylcellulose, mix well, and wash with 50% ethanol Wet granulation, drying at 60°C, adding 7 g of s...

specific Embodiment 2

[0026] Take 11.2g of Styrax, 56g of Gansong, 48g of Digupi, 120g of Radix Paeoniae Alba, 72g of Radix Glycyrrhizae, and 56g of Guizhi, grind them into 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 42Mpa, the extraction temperature is 39°C, separate The pressure of the separator is 19Mpa, the temperature of the separator is 55°C, the separation time is 3.4 hours, and the flow rate of carbon dioxide is 35L per hour to obtain the extract; take the extract and dry it under reduced pressure at 78°C to obtain a dry paste; take the dry paste and add 200g of mannitol, and use high-energy nano impact Grind and pulverize into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 55g of microcrystalline cellulose, 55g of cross-linked polyvinylpyrrolidone, and 45g of cross-linked sodium carboxymethylcellulose, mix well, and wash with 70% ethanol Wet granulation, drying at 80°C, add...

Embodiment 3

[0028] Take 11.2g of Styrax, 56g of Gansong, 48g of Digupi, 120g of Radix Paeoniae Alba, 72g of Radix Glycyrrhizae, and 56g of Cinnamon Twig, grind them into 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 29Mpa, the extraction temperature is 28°C, separate The pressure of the separator is 16Mpa, the temperature of the separator is 46°C, the separation time is 3.1 hours, the flow rate of carbon dioxide is 28L per hour, and the extract is obtained; the extract is dried under reduced pressure at 71°C to obtain a dry paste; the dry paste is added with 175g of mannitol, and the high-energy nano-shock is used Grind and pulverize into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 50g of microcrystalline cellulose, 50g of cross-linked polyvinylpyrrolidone, and 40g of cross-linked sodium carboxymethylcellulose, mix well, and wash with 60% ethanol Wet granulation, drying a...

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Abstract

The invention discloses Weiyankang capsules and a preparation method thereof. The preparation method is characterized by comprising the steps that 11.2 g of storax, 56 g of rhizoma nardostachyos, 48 g of cortex lycii radicis, 120 g of radix paeoniae alba, 72 g of liquorice and 56 g of cassia twigs are taken and extracted by adopting a supercritical carbon dioxide extraction method, drying under reduced pressure is performed, the dried materials are crushed into nano dry paste through a high-energy nano impact mill, functional auxiliary materials are added, and the Weiyankang capsules are prepared. The Weiyankang capsules have the advantages that the disintegration time is significantly shortened, the curative effect is significantly superior to that of commercially available Weiyankang capsules, and the positive effect is achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Weiyankang capsule and a preparation method thereof. Background technique [0002] Weiyankang Capsules soothe the liver and stomach, relieve spasms and relieve pain. Indications epigastric pain, nausea pantothenic acid, burning discomfort. For patients with the above symptoms such as duodenal ulcer, bile reflux gastritis, and chronic gastritis. The curative effect of Weiyankang Capsules on the market is not satisfactory due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect. Contents of the invention [0003] To overcome the above disadvantages, the present invention provides a Weiyankang capsule with fast disintegration speed and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follows: [0005] Take 11.2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/48A61P1/04
CPCA61K36/185A61K9/1652A61K36/484A61K36/54A61K36/65A61K36/71A61K36/815A61K47/10A61K47/12A61K47/32A61K47/36A61K47/38A61K2236/37A61K2236/51
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD