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New application of traditional Chinese medicine compound medicinal composition

A technology of raw materials and genes, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., to achieve good results in clinical application prospects

Active Publication Date: 2019-06-11
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report that Yougui Pill affects the differentiation of embryonic stem cells into germ cells

Method used

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  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 induction solution of the present invention

[0030] 1. Preparation of drug-containing serum

[0031] SD rats, clean grade, 6-8 weeks old, body weight 220-250g, ♀ For dual use, 15 animals each, license number: SCXK (Sichuan) 2004-15; provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences. The animals were kept in a clean animal room with a temperature of 22±2°C, a humidity of 40-70%, 10h / 14h alternating light and dark, automatic ventilation every 3min, regular full-price pellet feed, free drinking water, ♀ Separately reared in stainless steel cages.

[0032] Drug composition (rehmannia glutinosa 30g, dogwood 12g, yam 16g, medlar 12g, dodder 16g, antler gum 16g, Eucommia 16g, cinnamon 9g, angelica 16g, aconite 16g) was administered to mice, and the dosage was 5.0g / kg, the administration volume was 20ml / kg, and the rats in the blank group were fed with distilled water. Blood was collected from the fund...

Embodiment 2

[0035] Embodiment 2 The preparation of induction solution of the present invention

[0036] 1. Preparation of drug-containing serum

[0037] SD rats, clean grade, 6-8 weeks old, body weight 220-250g, ♀ For dual use, 15 animals each, license number: SCXK (Sichuan) 2004-15; provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences. The animals were kept in a clean animal room with a temperature of 22±2°C, a humidity of 40-70%, 10h / 14h alternating light and dark, automatic ventilation every 3min, regular full-price pellet feed, free drinking water, ♀ Separately reared in stainless steel cages.

[0038] Mice were gavaged with the pharmaceutical composition (rehmannia glutinosa 18g, dogwood 9g, yam 8g, medlar 9g, dodder 8g, antler gum 8g, Eucommia 1g, cinnamon 1g, angelica 1g, aconite 1g), and the dosage was 5.0g / kg, the administration volume was 20ml / kg, and the rats in the blank group were fed with distilled water. Blood was collected from the ...

Embodiment 3

[0041] Embodiment 3 The preparation of induction solution of the present invention

[0042] 1. Preparation of drug-containing serum

[0043] SD rats, clean grade, 6-8 weeks old, body weight 220-250g, ♀ For dual use, 15 animals each, license number: SCXK (Sichuan) 2004-15; provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences. The animals were kept in a clean animal room with a temperature of 22±2°C, a humidity of 40-70%, 10h / 14h alternating light and dark, automatic ventilation every 3min, regular full-price pellet feed, free drinking water, ♀ Separately reared in stainless steel cages.

[0044] Mice were gavaged with the pharmaceutical composition (Yougui Pills: Rehmannia glutinosa 24g, Cornus officinalis 9g, Chinese yam 12g, medlar 9g, dodder 12g, antler gum 12g, Eucommia 12g, cinnamon 6g, angelica 9g, aconite 6g), and the dosage The dose was 5.0g / kg, and the administration volume was 20ml / kg, and the rats in the blank group were fed with ...

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Abstract

The invention discloses an application of raw medicinal materials in preparation of an inducing liquid for promoting differentiation of embryonic stem cell into female germ cell, wherein the raw medicinal materials comprise, by weight, 18-30 parts of radix rehmanniae preparata, 9-12 parts of cornus officinalis, 8-16 parts of Chinese yam, 9-12 parts of wolfberry, 8-16 parts of semen cuscutae, 8-16 parts of deerhorn glue, 1-16 parts of eucommia, 1-9 parts of cinnamon, 1-16 parts of Chinese angelica and 1-16 parts of processed radix aconiti lateralis. The invention also discloses an inducing liquid for promoting differentiation of embryonic stem cell into female germ cell. The inducing liquid can induce differentiation of embryonic stem cell into female germ cell and has a good clinical application prospect.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine compound pharmaceutical composition, in particular, the application in preparing an induction solution for promoting the differentiation of embryonic stem cells to female germ cells. Background technique [0002] In recent years, due to serious environmental pollution, increased work pressure, changes in eating habits, reproductive system diseases and other factors that adversely affect normal conception, the number of infertile patients is on the rise, with an incidence rate of about 12.5% ​​to 15%. increasing trend year by year. Therefore, the World Health Organization (WHO) announced that infertility, cardiovascular disease, and tumors are listed as the three major diseases that affect human life and health today. Since the world's first test-tube baby was born in 1978, the introduction of assisted reproductive technology (ART) represented by in vitro fertilization-embryo ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/0735A61K36/8945A61P15/08A61K35/32
Inventor 陆华万谦刘志斌
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE