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Nematode-trapping fungus and vermifuge combined medication box and its application

An anthelmintic medicine and a medicine box technology, applied in the field of microbiology and parasitology, can solve the problems of intuition and speed, and achieve the effect of reducing the number of uses and improving the actual efficiency.

Inactive Publication Date: 2016-02-24
INNER MONGOLIA AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, judging from the current situation in our country, it is not realistic to use nematode-predating fungi alone to prevent and control nematode diseases in livestock, because it is not as intuitive and fast as the effect of anthelmintics

Method used

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  • Nematode-trapping fungus and vermifuge combined medication box and its application
  • Nematode-trapping fungus and vermifuge combined medication box and its application
  • Nematode-trapping fungus and vermifuge combined medication box and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Grouping of test animals:

[0029] Divide 40 experimental animals into 4 groups (Group A, Group B, Group C, Group D), with 10 sheep in each group. Among them, group A is a nematode-predating fungus-Duddingtoniaflagrans (D.flagrans) combined with albendazole (Albendazole, also known as albendazole) drug group; group B is a single albendazole drug group; Fungi-D.flagrans group; D group is the blank control group.

[0030] 2. Administration of experimental animals:

[0031] (1) The sheep in group A were fed with albendazole (12 mg / kg body weight) according to the dose in the drug instructions; and 1×10 6 A dose of chrystrophic spores / kg of body weight was fed with a suspension of chrystrophic spores prepared from a nematode-eating fungus-D.flagrans freeze-dried biological preparation.

[0032] (2) The sheep in group B were only fed albendazole, and the dosage was the same as that in group A.

[0033] (3) The sheep in group C were only fed the nematode-eating fungus-...

Embodiment 2

[0057] 1. Grouping of test animals:

[0058] Divide 40 experimental animals into 4 groups (Group E, Group F, Group C, Group D), with 10 sheep in each group. Group E is a nematode-predating fungus-Duddingtoniaflagrans (D.flagrans) combined with ivermectin drug group; Group F is a single ivermectin drug group; Group C is a nematode-predating fungus-D.flagrans group alone; D group For the blank control group.

[0059] 2. Administration of experimental animals:

[0060] (1) The sheep in group E were injected with ivermectin (0.2 mg / kg body weight) according to the dosage in the drug instructions; and 1×10 6 A dose of chrystrophic spores / kg of body weight was fed with a suspension of chrystrophic spores prepared from a nematode-eating fungus-D.flagrans freeze-dried biological preparation.

[0061] (2) The sheep in group F were only injected with ivermectin, and the dosage was the same as that in group A.

[0062] (3) The sheep in group C were only fed the nematode-eating fungus...

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Abstract

The invention belongs to the fields of microbiology and parasitology and provides a nematode-trapping fungus and vermifuge combined medication box. Effective ingredients of a vermifuge are chosen from common antinematodal drugs such as albendazole, ivermectin, avermectin and levamisole; for example, the ratio of an albendazole vermifuge or ivermectin vermifuge to a nematode-trapping fungus, per kilogram of animal body weight is 10-15 mg to 1*106 akinetes or 0.2 mg to 1*106 akinetes. The combined use mode of nematode-trapping fungi and vermifuges is provided to overcome the situation that the nematode-trapping fungi are independently used in China at present while chemical vermifuges cannot be quickly abandoned, after gastrointestinal nematodes are killed and decomposed by the medication, eggs and nematode-trapping fungi are jointly discharged out with excrement, when the eggs develop into larvae, the nematode-trapping fungi are stimulated to generate hyphae trap and network loops to trap the nematodes, thus avoiding the spread of the larvae causing new infections in livestock.

Description

technical field [0001] The invention belongs to the field of microbiology and parasitology, and in particular relates to a combination combination of nematode-eating fungi and anthelmintics. Background technique [0002] Animal parasitic nematode disease is a kind of common disease of livestock, which causes serious loss and harm to animal husbandry. For a long time, its control has mainly relied on some anthelmintic drugs to play a role. However, with the emergence of drug resistance from anthelmintics; the harm of drug residues in milk, meat, and eggs to human health; [0003] Nematode-predating fungi are natural enemies of nematodes. They capture and kill nematode larvae by forming predatory organs such as bacterial rings and fungal nets, so as to achieve the purpose of biological control of parasitic nematodes infection of livestock. It is precisely because of this characteristic of this type of fungus that predatory nematode fungi are extremely important and valuable ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K36/06A61P33/10A61K31/4184A61K31/7048A61K31/429A61K31/427
Inventor 杨晓野王瑞杨莲茹张伟乔蕾
Owner INNER MONGOLIA AGRICULTURAL UNIVERSITY
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