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Lead compound sulfo-methomyl and synthesis method thereof

A technology for a lead compound and a synthesis method, which is applied to the lead compound thiomethomyl and its synthesis field, can solve problems such as unfavorable large-scale production and complex preparation process, and achieve the effects of easy operation, reduced harm and convenient control

Inactive Publication Date: 2016-02-24
HENAN POLYTECHNIC UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] The chlorine gas used in the preparation process is a toxic gas, and the preparation and use of chlorine gas need to be completed by specific equipment and post-processing methods, so the preparation process is relatively complicated, which is not conducive to large-scale production

Method used

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  • Lead compound sulfo-methomyl and synthesis method thereof
  • Lead compound sulfo-methomyl and synthesis method thereof

Examples

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Embodiment 1

[0016] Synthesis of Butyl Chloride: Under the condition of stirring at -30°C, to a solution of 1,2-dibutyldisulfide (0.57mL, 3.0mmol) dissolved in toluene (1.25mL), slowly add pre-prepared sulfonyl chloride (2.4mL, 3.0mmol) of toluene (0.5mL) solution, and then the reaction solution was reacted at room temperature for 1.5h until the reaction substrate 1,2-dibutyl disulfide completely disappeared, the reaction solution turned orange, and was directly used for Next reaction.

[0017]

[0018] Synthesis of Buthiomethan : At room temperature, methomyl 1 (50mg, 0.31mmol) in carbon tetrachloride (2.5mL) suspension, were added triethylamine (0.17mL, 1.0mmol) and just prepared butyl thiochloride (0.4mL, 0.93mmol) solution, the reaction The solution was reacted at room temperature for 3 hours until the raw materials completely disappeared, the reaction solution was quenched with water, and then extracted with dichloromethane, the combined organic solution was dried over magnesiu...

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Abstract

The invention discloses a lead compound sulfo-methomyl and a synthesis method thereof and belongs to the technical field of pesticide or novel drug development. The lead compound sulfo-methomyl has a structural formula shown in the following description, wherein in the formula, R represents alkyl, alkenyl or aryl. The invention also discloses a synthesis method of the lead compound sulfo-methomyl. Compared with chlorine, the liquid sulfonyl chloride used in the preparation can be operated easily, is convenient for control, greatly reduces damage to an operator, has no special requirements on production equipment and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pesticide insecticide or new drug development, and specifically relates to a lead compound thiomethomyl and a synthesis method thereof. Background technique [0002] Methomyl is an oxime carbamate insecticide, acaricide, nematicide and molluscicide. It was developed by DuPont Company of the United States in 1966. It has the characteristics of strong lethality, fast effective period, wide insecticidal spectrum, low residue, many suitable crops and safe use. It has the functions of contact killing, stomach poisoning and egg killing. . Although methomyl is a mature product, the world market demand has been increasing at a moderate level. [0003] A lead substance, also known as a prototype or a lead compound, is a chemical structure with certain biological activity obtained through various approaches or methods. The lead substance may not be a good drug that can be used directly. It may not be directly me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C327/58A01N47/24A01P7/04A01P7/02A01P9/00
Inventor 周德军王强范云场
Owner HENAN POLYTECHNIC UNIV
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