Preparation containing 25-hydroxycholesterol and preparation method thereof and anti-virus application

Abstract

The invention relates to the field of medicinal preparations, in particular to a preparation containing 25-hydroxycholesterol and a preparation method thereof and application of related preparations in an anti-virus aspect. The preparation is basically prepared from, by weight, 10 parts of the 25-hydroxycholesterol and 5-50 parts of oil-phase liquid. According to the preparation, not only is the specific anti-ebola virus effect achieved, but also the more broad-spectrum anti-virus effect is achieved; the compound 25-hydroxycholesterol is successfully converted into the medicinal preparation which can be produced and actually used for the first time, and the prepared preparation is high in dissolution rate and bioavailability and good in stability; in addition, the preparation technology is simple, and the cost is low; viruses such as an ebola virus can be killed efficiently, safely and quickly, and the great application prospect and economic value are achieved; meanwhile, a positive promoting role in control over the epidemic situation such as the ebola virus is played, and the historical significance is achieved.

Description

technical field The present invention relates to the field of pharmaceutical preparations, in particular, to a preparation containing 25-hydroxycholesterol, a preparation method thereof, and an antiviral application of the related preparation. Background technique Ebola hemorrhagic fever is an acute hemorrhagic infectious disease caused by Ebola virus disease (EBOV). It is mainly infected through contact with the blood, body fluids, secretions and excreta of patients or infected animals. The main clinical manifestations are prominent fever, bleeding and multiple organ damage. The fatality rate of Ebola hemorrhagic fever is high, which can reach 50% to 90%. The disease was first discovered in Africa in 1976, and is mainly popular in African countries such as Uganda, Congo, Gabon, and Sudan. The outbreak, which began in Guinea in December 2013 but was not detected until March 2014, has now spread to Liberia, Sierra Leone and Nigeria. As of August 13, 2014, the World Healt...

AI Technical Summary

Problems solved by technology

Few have discovered its antiviral effects, let alone against Ebola, and certainly no one has succeeded in developing it as a drug or agent for related viruses

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