Application of GSPE (grape seed proanthocyanidin extract) in preparation of targeted drug for treating cell calcium overload injury
A calcium overloading and cellular technology, which is applied in the field of medicine, can solve the problem that the metabolism of calcium ions in cells has not been reported, and achieve the effect of reversing the damage caused by calcium overloading in cells
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[0019] The present invention will be further described below in conjunction with the embodiments. The following descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention to other forms. Changes to equivalent embodiments with equivalent changes. Any simple modifications or equivalent changes made to the following embodiments according to the technical essence of the present invention without departing from the solution content of the present invention fall within the protection scope of the present invention.
[0020] In this study, a BALB / c mouse model with defective Orai1 gene expression was constructed by gene knockout method, and the sepsis model of intraperitoneal infection of BALB / c mice was replicated by cecal ligation and perforation CLP method. Calcium imaging and molecular biology methods were used to determine that Orai1-mediated SOCE was the main mechanism involved in calcium overload injury in sepsis c...
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