Huoxiang Zhengqi capsule and preparation method thereof

A patchouli, internal injury technology, applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of slow disintegration, unsatisfactory curative effect, and low curative effect

Inactive Publication Date: 2016-03-30
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Huoxiangzhengqi Capsules available in the market are not very effective due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Huoxiang Zhengqi capsule and preparation method thereof
  • Huoxiang Zhengqi capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 146g of coix seed, 73g of Gorgon fruit, 36.5g of goose herb, 195g of patchouli, 73g of perilla leaf, 73g of Angelica dahurica, 146g of Atractylodes macrocephala (fried), 146g of tangerine peel, 130g of French pinellia, 130g of Magnolia officinalis (made from ginger), Poria cocos 60g, bellflower 146g, pulverized into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 20Mpa, extraction temperature 17°C, separator pressure 11Mpa, separator temperature 36°C, separation time 2.2 hours, carbon dioxide flow per hour 25L to obtain the extract; take the extract and dry it under reduced pressure at 61°C to obtain a dry paste; add 150g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 45g, cross-linked polyvinylpyrrolidone 45g, cross-linked carmellose sodium 35g, mix well, ...

specific Embodiment 2

[0032] Take 146g of coix seed, 73g of Gorgon fruit, 36.5g of goose herb, 195g of patchouli, 73g of perilla leaf, 73g of Angelica dahurica, 146g of Atractylodes macrocephala (fried), 146g of tangerine peel, 130g of French pinellia, 130g of Magnolia officinalis (made from ginger), Poria cocos 60g, bellflower 146g, pulverized into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 40Mpa, extraction temperature 37°C, separator pressure 20Mpa, separator temperature 59°C, separation time 3.7 hours, carbon dioxide flow per hour 33L to obtain the extract; take the extract and dry it under reduced pressure at 79°C to obtain a dry paste; add 200g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 55g, crospovidone 55g, croscarmellose sodium 45g, mix well, wet granulate with 70% ethanol...

Embodiment 3

[0034] Take 146g of coix seed, 73g of Gorgon fruit, 36.5g of goose herb, 195g of patchouli, 73g of perilla leaf, 73g of Angelica dahurica, 146g of Atractylodes macrocephala (stir-fried), 146g of orange peel, 130g of French pinellia, 130g of Magnolia officinalis (made from ginger), Poria cocos 60g, Platycodon grandiflorum 146g, crushed into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 30Mpa, extraction temperature 27°C, separator pressure 16Mpa, separator temperature 48°C, separation time 3 hours, carbon dioxide flow per hour 29L to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 175g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 50g, crospovidone 50g, croscarmellose sodium 40g, mix well, wet granulate with 6...

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Abstract

The invention discloses a Huoxiang Zhengqi capsule and a preparation method thereof. The Huoxiang Zhengqi capsule is characterized in that 146 g of coix seeds, 73 g of gorgon euryale seeds, 36.5 g of small centipeda herb, 195 g of pogostemon cablin, 73 g of perilla leaf, 73 g of radix angelicae dahuricae, 146 g of atractylodes macrocephala koidz (stir-fried), 146 g of tangerine peel, 130 g of rhizoma pinelliae preparatum, 130 g of mangnolia officinalis (ginger mix frying), 60 g of poria cocos and 146 g of platycodon grandiflorum are taken and extracted by adopting a carbon dioxide supercritical extraction method, the extract is dried under reduced pressure and is smashed through a high energy nanometer impacting grinding into nanometer dry paste, functional accessories are added, and the Huoxiang Zhengqi capsule is prepared. The disintegration time is remarkably shortened, the treatment effect is remarkably better than that of a Huoxiang Zhengqi capsule sold in the market, and the positive effect is achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Huoxiangzhengqi capsule and a preparation method thereof. Background technique [0002] Huoxiang Zhengqi Capsule relieves surface and eliminates dampness, regulates qi and harmonizes neutrality. For exogenous wind-cold, internal injury stagnation of dampness, headache, dizziness, fullness of chest and diaphragm, abdominal pain, vomiting and diarrhea. The commercially available Huoxiang Zhengqi Capsules have unsatisfactory curative effect due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides Huoxiangzhengqi capsules with fast disintegration speed and high curative effect and a preparation method thereof. [0004] Invention embodiment is a...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K9/48A61K47/38A61P11/00A61P25/00A61P1/00A61P1/08A61P1/12
CPCA61K36/8994A61K9/1652A61K36/076A61K36/232A61K36/28A61K36/284A61K36/346A61K36/53A61K36/535A61K36/575A61K36/62A61K36/752A61K36/8888A61K2236/37
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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