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A kind of health care medicine preparation with magnesium supplementation and antioxidant effect and preparation method thereof

A technology of anti-oxidative effect and preparation, applied in the direction of anti-toxic agent, anti-inflammatory agent, antipyretic drug, etc., can solve the limitation of the effect of hydrogen supplementation health care products, about 0.1-1ppm, the highest is only about 5ppm, inconvenient for storage and placement, etc. problems, to achieve no toxic side effects or adverse reactions, facilitate large-scale production, and improve the efficiency of conversion and absorption

Active Publication Date: 2020-07-14
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogen-rich water is limited by the low solubility of hydrogen, and the hydrogen content is generally only about 0.1-1ppm, and the highest is only about 5ppm
Low hydrogen concentration and poor stability are currently the biggest problems restricting the effectiveness of hydrogen supplement health products
[0004] Moreover, there is no preparation or health care product that can supplement magnesium and hydrogen at the same time in China. Only the Dr. Hydrogen-rich water bar introduced from Japan has the active ingredient of metal magnesium, but the problem is that 1) hydrogen will be generated when it meets water Magnesium oxide is insoluble in water, so it cannot be effectively used, and the content of magnesium entering the human body is too low; 2) Hydrogen gas is easily escaped and unstable when it meets water, so it must be taken immediately, and it is inconvenient to store and place, and the concentration of hydrogen dissolved in water is limited ;3) Magnesium metal particles are easily oxidized into insoluble matter, which prevents further reaction with water, so as the number of uses increases, the effect decreases significantly
The patent CN102557227B "A calcium-magnesium hydrogen-rich water additive and its preparation method" is similar to the principle of the above-mentioned hydrogen-rich water stick. The hydrogen-producing agent is magnesium element or calcium-magnesium alloy, but an additional pH regulator is added to improve the dissolution of magnesium. But the above problem 2) still exists unresolved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Magnesium hydride is prepared into micropowder with a size of 100-200 nanometers, 250g of powder is taken, 500g of pregelatinized starch and 250g of microcrystalline cellulose are added, mixed evenly, and pressed into 1000 tablets to obtain the product. Each tablet weighs 1g, adults take 2 tablets a day, swallowed in 1-2 times, children take 1 tablet a day, once a day. After taking it continuously for 1-2 weeks, the leg muscle soreness caused by mountain climbing or long-distance running will be effectively relieved and disappeared due to the effective supplement of magnesium.

Embodiment 2

[0029] Prepare magnesium hydride into 400-600 mesh micropowder, take 150g of powder, add 150g of mannitol, 120g of micropowdered silica gel, and 80g of alginic acid, grind and sieve, mix well and put it into capsules to obtain a total of 1000 capsules. Each capsule weighs 0.5g. Adults take 2-3 capsules a day, divided into 1-3 times, and children take 1-2 capsules a day, divided into 1-2 times. It has been confirmed by animal experiments that mice suffering from pneumonia took the above-mentioned medicinal powder in the capsule continuously for 2 weeks, and 1 capsule of the medicinal powder was mixed into the rat food every day. Obtain effective treatment and alleviate in 2 weeks, take 3 weeks back pneumonia complete recovery from illness.

Embodiment 3

[0031] Magnesium hydride is prepared into a micropowder of 500 nanometers to 1 micron, 200g of the powder is taken, 150g of lactose, 100g of dextrin, and 50g of CMC are added, mixed evenly, and processed into pills to obtain 1000 pills in total. Each capsule weighs 0.5g, 1-2 capsules per day for adults, 1-2 capsules per day for children, swallowed 1-2 times a day. It has been confirmed by animal experiments that guinea pigs suffering from hepatitis took the above-mentioned pills continuously for one month, and one pill per day of the powder was mixed into the rat food for consumption. The hepatitis inflammation of guinea pigs played an effective anti-inflammatory and anti-oxidative effect due to hydrogen entering the body fluid. Symptoms were effectively treated and alleviated in ten days, and the hepatitis was fully recovered after taking 4 weeks.

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Abstract

A healthcare pharmaceutical preparation having magnesium supplementation and anti-oxidation effects, and a preparation method for the healthcare pharmaceutical preparation. The healthcare pharmaceutical preparation comprises a main effective component, which is a magnesium agent, and an excipient, the magnesium agent being an MgH2 micro / nanopowder, the excipient being a commonly used pharmaceutical preparation excipient.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a health-care pharmaceutical preparation that supplements magnesium and has anti-oxidation effects. Background technique [0002] Along with the raising of people's living standard and population aging, and the change of lifestyle, health care is paid more and more attention to by people. Some trace elements play a very important role in human health, such as magnesium, which participates in the synthesis of all energy metabolism proteins in the body, activates and catalyzes a variety of enzyme systems, regulates the nervous system, ensures normal myocardial contraction, enhances the body's immune function, and protects bones health etc. Magnesium deficiency in the human body may cause symptoms such as cardiovascular and cerebrovascular diseases, high blood pressure, diabetes, osteoporosis, migraine, anxiety and depression, and seriously endanger human health. Therefo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/06A61P39/06A61P3/02A61P21/00A61P29/00A61P25/20
CPCA61K9/2059A61K9/2826A61K9/4866A61K33/06
Inventor 袁广银裴佳丁文江
Owner SHANGHAI JIAO TONG UNIV
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