Filter device for filtering complex fluid samples

Abstract

A filter device (1) for filtering complex fluid samples, comprising a first filter funnel (2) having an inlet (2a) and an outlet (2b) and an internal space (2c) dimensioned to receive a volume of sample fluid to be filtered, and a second filter funnel (3) having an inlet (3a) and an outlet (3b) and an internal space (3c) dimensioned to receive the volume of sample fluid. The first and second filter funnels (2,3) are sequentially arranged with a first filter medium (4) located therebetween such that the volume of sample fluid placed in the internal space (2c) of the first filter funnel (2) can pass through the first filter medium (4) and be collected in the internal space (3c) of the second filter funnel (3). An intermediate connector (12) is provided downstream of the first filter medium (4) and upstream of the internal space (3c) of the second filter funnel (3) and has a port (13) and / or a vent for communicating the internal space (3c) of the second filter funnel (3) with an external gas source / atmosphere and / or a vacuum source via a valve arrangement (14).

Description

technical field [0001] The present invention relates to a filter device for filtering complex fluid samples. The invention is particularly applicable in the fields of biopharmaceutical, pharmaceutical, hospital and food and beverage industries for performing bioburden tests using filtered complex fluid samples. Background technique [0002] Filtration of complex certain fluid samples requires a two-stage filtration process through a first filter or pre-filter comprising a membrane with large pores that keep larger particles separated from the fluid sample while the filtrate collects in downstream containers. The filtrate is then processed by normal filtration in the second stage. [0003] If the two stages are performed in different vessels or processes, handling is complicated and the risk of contamination of retentate and / or filtrate and / or sample fluid prior to testing is high at any point in and between stages. Furthermore, the capacity of the filter device for this c...

AI Technical Summary

Problems solved by technology

A disadvantage of this combined device is the small volume and capacity, as well as the difficulty in handling, for example, opening and closing the corresponding filter funnel of the device

Given that the material is stainless steel, this leads to a relatively high risk of contamination during handling and to high cleaning and autoclaving requirements for the system

Another disadvantage of this device is the lack of possibility to observe the development of the corresponding filtration step, so that there is a high risk of the device opening before the filtration is complete

At the same time, if the filter membrane of the pre-filter stage is clogged, for example, the opening of the filter unit presents a risk of spillage and / or contamination of the fluid sample still in the container

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