Pharmaceutical composition and preparation method thereof

A composition and drug technology, applied in the field of medicine, to achieve the effects of enhancing memory, convenient administration, and small dosage

Active Publication Date: 2016-05-04
THE HONG KONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no report of a pharmaceutical composition or traditional Chinese medicine compound that can exert anti-senile dementia and anti-depression effects by promoting nerve cell differentiation

Method used

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  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] In a specific embodiment, the preparation method of the pharmaceutical composition comprises the following steps:

[0054] Take ginseng, Polygala, Shichangpu, and Poria and cut them into pieces; weigh ginseng-polygala (weight ratio 1:1) and Shichangpu-Poria (weight ratio 1:2), and soak them in 6-10 times of water for 20-40 Minutes, extract 1-3 times, 1-3 hours each time, combine extracts, freeze-dry to obtain water extract powder. Combine the water extract of ginseng-Polygalae medicine pair and Shichangpu-Poria cocos medicine pair water extract in a weight ratio of 1:5, and mix well.

[0055] In a more specific embodiment, ginseng, Polygala, Shichangpu and Poria are respectively cut into pieces. Take ginseng and polygala (weight ratio 1:1), put them in a 500mL conical flask, add 120-200g of water, soak for 20-40 minutes, heat and extract for 1-3 hours, filter while hot, and heat the residue as above Extract 1-2 times and combine the filtrates. The filtrate was lyophi...

Embodiment 1

[0068] Embodiment 1: the preparation of compound medicine combination

[0069] Take respectively 10 g of ginseng (dried root of Araliaceae plant ginseng (Panaxginseng C.A.Mey.), Polygala (dried root of Polygalate nuifolia Willd. or Polygalasibirica L.), 10 g of Polygala (Panaxginseng C.A. Mey.), 10g of dried rhizome of Araceae plant Acorus tarinowii Schott), 20g of Poria cocos (dried sclerotia of Polyporaceae fungus Poriacocos (Schw.) Wolf) and cut into pieces. Take ginseng and polygala, put them in a 500mL Erlenmeyer flask, add 160g of water, soak for 30 minutes, heat and extract for 2 hours, filter while hot, heat and extract the residue once according to the above method, and combine the filtrates. The filtrate was lyophilized to obtain the aqueous extract lyophilized powder I. Then take the two flavors of Acorus calamus and Poria, put them in a 500mL Erlenmeyer flask, add 240g of water, soak for 30 minutes, heat and extract for 2 hours, filter while hot, heat and extract ...

Embodiment 2

[0070] Embodiment 2: the quality control of ginseng-polygala medicine pair and Shichangpu-Poria cocos medicine pair

[0071] Based on the research on the chemical constituents and functions of ginseng, Polygalaceae, Shichangpu and Poria cocos, select ginsenoside Rb 1 , Rd, Re, Rg 1 , Polygala 3,6-di-mustardyl sucrose, Acorus α-asarone and β-asarone and Poria cocos as index components.

[0072] Accurately weigh 1 mg of the water extract freeze-dried powder I and II of Example 1, the single drug water extract freeze-dried powder and the water extract freeze-dried powder mixed with the four drugs, add it to 5 mL of 50% ethanol solution, and ultrasonicate for 30 Minutes, through a 220μM filter membrane, that is, the test product.

[0073] The test substance was determined by LC-MS system (liquid-mass spectrometry system). HPLC system (Agilent1290, binary pump, autosampler, DAD detector, column thermostat), C18 reverse column (Agilent ZORBAX Eclipse XDB-C18column (1.8mm, 50mm×4....

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Abstract

The present application relates to a pharmaceutical composition, which comprises a ginseng-polygala tenuifolia willd drug pair or an extract thereof, and / or acorus tatarinowii-tuckahoe drug pair or an extract thereof. The present invention further relates to a preparation method of the pharmaceutical compositions, and uses of the pharmaceutical composition in preparation of drugs for memory enhancing or treatment of neurodegenerative diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition and a preparation method thereof, in particular to a compound Chinese medicine composition and a preparation method thereof. The present invention also relates to the application of the above pharmaceutical composition in nerve-related diseases. Background technique [0002] Depression and senile dementia (also known as Alzheimer's disease) are two major diseases in neuropathy that are more concerned by the society. Depression is a disease characterized by significant and persistent low mood, accompanied by symptoms such as insomnia, memory loss, and eating disorders. In severe cases, suicidal thoughts and behaviors may appear. Most cases have a tendency to relapse, and most of each attack can be relieved, and some may have residual symptoms or become chronic. It has been reported that 16% of the population will experience symptoms of depression at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/28A61P25/24
Inventor 詹华强董婷霞颜露朱悦
Owner THE HONG KONG UNIV OF SCI & TECH
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