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C3N4 nanocomposite, preparation method and application of C3N4 nanocomposite

A nanocomposite material, C3N4 technology, applied in the field of nanomedical materials and nanomedical materials for tumor treatment, can solve problems such as limiting the treatment efficiency of photodynamic therapy

Inactive Publication Date: 2016-05-04
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although photodynamic therapy has become a promising treatment option for early and advanced tumors, the hypoxia at the tumor site severely limits the therapeutic efficiency of photodynamic therapy.

Method used

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  • C3N4 nanocomposite, preparation method and application of C3N4 nanocomposite
  • C3N4 nanocomposite, preparation method and application of C3N4 nanocomposite

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preparation example Construction

[0035] The present invention also provides a kind of above-mentioned C 3 N 4 The preparation method of nanocomposite material, comprises: the C that loads transition metal element 3 N 4 Two-dimensional nanosheets and photosensitizers were mixed in water and stirred in the dark to obtain C 3 N 4 nanocomposites.

[0036] Wherein, the C of the loaded transition metal element 3 N 4 The two-dimensional nanosheets and the photosensitizer are the same as those described above, and will not be repeated here. The present invention has no special limitation on the sources of all raw materials, which can be commercially available or self-made.

[0037] The C of the loaded transition metal element 3 N 4 The two-dimensional nanosheets were prepared according to the following method: C 3 N 4 Ultrasonic exfoliation of nanomaterials in water to obtain C loaded with transition metal elements 3 N 4 Two-dimensional nanosheets. Wherein, the C of the layered loaded metal element 3 N...

Embodiment 1

[0049] 1.1 Weigh 10g of dicyandiamide and 1g of ferric chloride dissolved in 50mL of ultrapure water, stir at 80°C until the water is completely evaporated; put the obtained brick red solid powder into a tube furnace, under the protection of nitrogen, The temperature was programmed to 600 °C at a rate of 2.3 °C per minute and maintained at 600 °C for 4 hours, and then cooled naturally to obtain a light brown layered C 3 N 4 -Fe nanomaterials.

[0050] 1.2 Weigh 100mg of layered C obtained in 1.1 3 N 4 - Fe nanomaterials, dispersed in 100mL ultrapure water, ultrasonically stripped for 16 hours; centrifuge the above mixed solution at a centrifugal force of 5000g for 10 minutes, discard the bottom sediment, continue to centrifuge the supernatant at 10000g for 10 minutes, discard the supernatant , the bottom product obtained is C 3 N 4 -Fe two-dimensional nanosheets.

[0051] 1.3 Weigh the C obtained in 1mg1.2 3 N 4 -Fe two-dimensional nanosheets were dispersed in 10 mL of...

Embodiment 2

[0054] 2.1 Weigh 10g of dicyandiamide and 1g of cobalt chloride dissolved in 50mL of ultrapure water, stir at 80°C until the water is completely evaporated; put the obtained red solid powder into a tube furnace, and under the protection of nitrogen, The temperature was programmed to 600 °C at a rate of 2.3 °C per minute and maintained at 600 °C for 4 hours, and then cooled naturally to obtain a pink layered C 3 N 4 -Co nanomaterials;

[0055] 2.2 Weigh 100 mg of layered C obtained in 2.1 3 N 4 -Co nanomaterials, dispersed in 100mL ultrapure water, ultrasonically stripped for 16 hours; centrifuge the above mixed solution for 10 minutes under a centrifugal force of 5000g, discard the bottom sediment, continue to centrifuge the supernatant at 10000g for 10 minutes, discard the supernatant , the bottom product obtained is C 3 N 4 -Co two-dimensional nanosheets.

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Abstract

The invention provides a C3N4 nanocomposite, a preparation method and application. The C3N4 nanocomposite takes a C3N4 two dimensional nanosheet loading a transition metal element as a carrier, and a photosensitizer is loaded on the carrier. Compared with the prior art, the C3N4 two dimensional nanosheet loading the transition metal element is taken as the carrier, the photosensitizer is loaded on the carrier, the C3N4 nanocomposite can enter a cancer cell by effective endocytosis of the cell, the transition metal element can perform catalytic decomposition on hydrogen peroxide in the cancer cell to generate oxygen, under the irradiation of laser, the photosensitizer can effectively and quickly convert oxygen molecules into singlet oxygen, and thus generates toxicity to the cancer cell and kills the cancer cell, and accordingly an effect of treating tumor by photodynamics is achieved.

Description

technical field [0001] The invention belongs to the technical field of nanomedical materials and nanomedical materials for tumor treatment, and in particular relates to a C 3 N 4 Nanocomposites, preparation methods and applications. Background technique [0002] Cancer is one of the leading causes of human death, currently killing more than 7 million people worldwide each year, and this number will rise rapidly. Although current detection methods and treatment techniques have made significant progress, regular detection and early intervention are the best ways to improve efficacy and survival chances. At present, chemotherapy, radiotherapy and surgery are the main tumor treatment methods commonly used in clinical practice, but these treatment methods all have relatively high side effects and recurrence rates. Therefore, seeking an effective, non-toxic and low-cost tumor treatment method to replace the above-mentioned therapies is a challenge for current tumor treatment. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61P35/00
CPCA61K41/0057A61K41/0061A61K47/02
Inventor 姜秀娥马志方白静贾潇丹
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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