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Microfluidic chip, blood cell separation method and system, and manufacturing method of the system

A microfluidic chip and chip technology, applied in the field of blood cell separation, can solve the problems of insufficient miniaturization and light weight, low separation efficiency, etc., and achieve the effects of light weight, reduced clogging and avoiding clogging

Active Publication Date: 2017-07-07
TSINGHUA UNIV
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Problems solved by technology

[0003] The purpose of the present invention is to provide a microfluidic chip, a whole blood cell separation system based on the chip, a manufacturing method of the system and a method for separating blood cells by using the system, which are used to separate blood cells and can overcome The defects of low separation efficiency, miniaturization and light weight of the existing technology meet the needs of on-site instant blood sample separation

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  • Microfluidic chip, blood cell separation method and system, and manufacturing method of the system
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Embodiment Construction

[0050] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are the Some, but not all, embodiments are invented. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0051] Such as Figure 1 to Figure 3 As shown, the present embodiment discloses a microfluidic chip, the chip is composed of a microporous membrane layer 13, a substrate layer 11 (the material is a non-magnetic, transparent material) containing a main channel structure, and a layer containing an upper flow channel. composed of a flexible polymer layer 15 with channel s...

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Abstract

The invention discloses a microfluidic chip, a whole blood hemocyte separation system based on the chip, a preparation method of the system and a method for separating whole blood hemocytes by using the system, is used for separating the hemocytes, can overcome the defects of low separation efficiency and insufficient miniaturization and lightweight in the prior art, and meets on-site real-time blood sample separation requirements. The chip is prepared by successively bonding a substrate layer containing a main flow channel structure with a microporous filter membrane layer and a flexible polymer layer containing an upper-layer flow channel structure, and a micro-channel system is formed in the chip; the micro-channel system includes a micro-pump area, a circulation area, a first channel, a second channel, a third channel, and a filtering area formed by the main flow channel structure, the microporous filter membrane layer and the upper-layer flow channel structure.

Description

technical field [0001] The invention relates to the technical field of blood cell separation, in particular to a microfluidic chip, a whole blood cell separation system based on the chip, a manufacturing method of the system, and a method for using the system to separate whole blood cells. Background technique [0002] White blood cells contain a wealth of immune system information, and many tests for white blood cells require their isolation from whole blood. Some traditional separation methods, such as centrifugation, require large equipment, large sample requirements, and complicated operations, making it difficult to integrate with subsequent detection and analysis instruments. The use of microfluidic chips to separate white blood cells is the basis for the detection and analysis of white blood cells based on microfluidic chips. Efficient isolation of leukocytes from whole blood in microfluidic chips remains challenging due to the high concentration of blood cells and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00C12M1/36C12M1/12C12N5/078
CPCB01L3/50273B01L3/502753B01L3/502761B01L2300/0681B01L2300/0819B01L2400/0403C12N5/0634
Inventor 叶雄英成一诺马增帅谢帅张帅
Owner TSINGHUA UNIV
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