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Polyethylene glycol-containing composition

A technology of polyethylene glycol and composition, which is applied in the field of stabilizing the compound represented by the formula or its salt, can solve problems such as unrecorded, and achieve the effect of sufficient safety

Inactive Publication Date: 2016-05-04
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, patent documents 1 to 6 do not describe a pharmaceutical composition containing a compound represented by formula (1) or a salt thereof and polyethylene glycol. In addition, polyethylene glycol can increase the concentration of pharmacologically active compounds in the pharmaceutical composition. There is no record of stability

Method used

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  • Polyethylene glycol-containing composition
  • Polyethylene glycol-containing composition
  • Polyethylene glycol-containing composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0108] This compound 0.01~20g

[0109] Appropriate amount of PEG400

preparation example 2

[0111] This compound 0.01~20g

[0112] Dimethyl sulfoxide 0.1~30g

[0113] Appropriate amount of PEG400

preparation example 3

[0115] This compound 0.01~20g

[0116] Polysorbate 200.0001~20g

[0117] Appropriate amount of PEG400

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PUM

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Abstract

The present invention relates to a pharmaceutical composition including: polyethylene glycol; and a compound represented by formula (1), or a salt thereof.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing a compound represented by formula (1) or a salt thereof and polyethylene glycol, and a method for stabilizing the compound represented by formula (1) or a salt thereof. [0002] [0003] [In formula (1), [0004] R 1 Indicates hydrogen atom, halogen atom, hydroxyl, C 1－6 Alkyl, C substituted by 1 or more halogen atoms 1－6 Alkyl, C 1－6 Alkoxy or C substituted by 1 or more halogen atoms 1－6 alkoxy; [0005] R 2 Represents a hydrogen atom, C 1－6 Alkyl, C 1－6 Alkylcarbonyl or C substituted by 1 or more hydroxyl groups 1－6 Alkylcarbonyl] Background technique [0006] Patent Document 1 describes that the compound represented by formula (1) exhibits a cell proliferation inhibitory effect in a test system using a VEGF-induced HUVEC proliferation response evaluation system, and shows a cell proliferation inhibitory effect in a test system using a mouse tumor-bearing model. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/444A61K9/08A61K47/34A61P3/10A61P27/02A61P27/06A61P35/00
CPCA61K9/0048A61K47/10A61K31/444A61P27/02A61P27/06A61P35/00A61P9/00A61P3/10
Inventor 村井健二山田和人
Owner SANTEN PHARMA CO LTD