Cyclodextrin-Auricularia auricula micropowder combination and preparation method and preparation thereof

A technology of black fungus and cyclodextrin, which is used in pharmaceutical formulations, plant raw materials, and medical preparations with inactive ingredients, etc. Stable ingredients, improved water solubility and stability, and increased effect of ingredient dissolution

Inactive Publication Date: 2016-05-25
NANJING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the black fungus is ultrafinely pulverized, the stability of the active ingredients decreases, the loss of the reducing ingredients is serious, and the product is difficult to preserve for a long time. In addition, the pulverized micropowder has strong hygroscopicity, and it is easy to agglomerate when it meets water and is not easy to disperse. The dissolution and release of active ingredients are restricted, and there is a serious sticking phenomenon that affects the taste comfort when taking it. The characteristics of moisture absorption and agglomeration also increase the difficulty of later preparations and reduce the actual application value of the product. These practical problems have not been recognized for a long time. attention

Method used

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  • Cyclodextrin-Auricularia auricula micropowder combination and preparation method and preparation thereof
  • Cyclodextrin-Auricularia auricula micropowder combination and preparation method and preparation thereof
  • Cyclodextrin-Auricularia auricula micropowder combination and preparation method and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Black fungus 4000g, soak in warm water for 4 hours, ultrasonically clean for 10 minutes, remove roots and impurities, drain, then mix with 4000g β-cyclodextrin, add a little water to mix evenly, put it into a colloid mill for grinding, and adjust the fineness after the crushing system of large black fungus is uniform Continue to grind for 10 minutes in the machine gap until it becomes a fine slurry, discharge the material, put it into a rake vacuum dryer, control the reduced pressure at 60°C to remove water, and discharge the material, dry it with a microwave dryer for 0.5 hours under reduced pressure, and pass through a 200-mesh sieve , to get 7134g cyclodextrin-black fungus powder product.

Embodiment 2

[0080] It is basically the same as Example 1, but it is prepared by adding 4000g of black fungus and 6000g of β-cyclodextrin and mixing to obtain 9072g of cyclodextrin-black fungus micropowder.

Embodiment 3

[0082] Basically the same as Example 1, but prepared with 2000g of hydroxypropyl-β-cyclodextrin instead of β-cyclodextrin to obtain 5377g of cyclodextrin-black fungus micropowder.

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Abstract

The invention discloses a cyclodextrin-Auricularia auricula micropowder combination which is mainly prepared from cyclodextrin and Auricularia auricula. The invention further discloses a preparation method of the combination, a preparation comprising the combination and a preparation method of the preparation. Compared with the prior art, the cyclodextrin-Auricularia auricula micropowder combination and the preparation have the advantages that release of active ingredients can be promoted, water solubility of the active ingredients can be improved, and protein ingredient stability of Auricularia auricular, dispersity and performance of the preparation can be improved.

Description

technical field [0001] The invention relates to a cyclodextrin-black fungus micropowder composition, a preparation method and a preparation thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] Edible fungi are large fungi that humans can eat. There are about 2,000 species of edible fungi in nature, and it is estimated that there are at least 1,500 or nearly 2,000 species in my country. Black fungus is a famous edible fungus, mycological classification belongs to Basidiomycetes, Auricularia, Auriculariaceae. As food, black fungus has a history of thousands of years. Edible black fungus includes black fungus, hairy black fungus, swallow's ear, white fungus, wrinkled black fungus, autumn black fungus, purple black fungus and so on. Black fungus is first recorded in "Shen Nong's Materia Medica", which contains the title of five black fungus. "Lu's Spring and Autumn" mentioned: "The most delicious taste is the fungus of Yueluo." Blac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61K47/48A61K9/16A61K47/69
CPCA61K9/1652A61K36/06A61K2236/331
Inventor 任勇袁放赵元永
Owner NANJING NORMAL UNIVERSITY
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