Voriconazole copper nitrate complex with bacteriostatic activity and preparation method thereof

Abstract

The invention provides a voriconazole copper nitrate complex with bacteriostatic activity and a preparation method thereof. A synthesis method comprises the steps of dissolving voriconazole (FZ for short) and copper nitrate in a certain volume of water and organic solvent, cooling a reaction mixture to room temperature after heating is completed, carrying out filtering and standing so as to separate out a blue target product, and determining the crystal structure of the target product by monocrystalline X-rays; and the chemical formula of the product is [Cu(FZ)2(NO3)2]. Ultraviolet, infrared and antibacterial activities are further researched. The complex has high antibacterial activity to Achromobacter xylosoxidans, Bacillus subtilis, Candida glabrata, Cryptococcus neoformans, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus and the like. The compound can serve as an excellent novel antibacterial agent product.

Description

technical field [0001] The invention belongs to the fields of inorganic chemistry, organic chemistry, biochemistry and medicinal chemistry, and relates to the synthesis method, structure analysis, ultraviolet, infrared and antibacterial activity research of metal complexes. Background technique [0002] The complexes have potential applications in bioactivity, catalysis, and optics. It is worth noting that the structure of the complex is affected by many factors during the self-assembly process (temperature, pH value, metal salt, auxiliary ligand structure, solvent ratio, etc.), therefore, the design and control of synthesizing the target complex is still facing a challenge. Great challenge (X.G.Guo, W.B.Yang, X.Y.Wu, Q.K.Zhang, L.Lin, R.Yu, C.Z.Lu, CrystEngComm, 2013, 15, 3654-3663). Modern medical research shows that copper complexes can produce antibacterial, antiviral, anti-inflammatory, antitumor, enzyme inhibition or chemical nuclease activities, which has attracted m...

AI Technical Summary

Problems solved by technology

[0006] The invention solves the problems of high synthesis cost and low antibacterial activity of the existing antibacterial agents, and provides a voriconazole copper nitrate complex with antibacterial activity and a preparation method thereof. The compound has strong antibacterial activity and the preparation method thereof Simple, short synthesis time, abundant and versatile raw material sources

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