Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Voriconazole copper nitrate complex with bacteriostatic activity and preparation method thereof

A technology of antibacterial activity and azole copper nitrate, which is applied in the research of infrared and antibacterial activity, ultraviolet, and the synthesis field of metal complexes, can solve the problems of low antibacterial activity and high cost of synthesis of bacteriostatic agents, and achieves less defects and better materials. Application prospect, high yield effect

Inactive Publication Date: 2016-06-01
QILU UNIV OF TECH
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention solves the problems of high synthesis cost and low antibacterial activity of the existing antibacterial agents, and provides a voriconazole copper nitrate complex with antibacterial activity and a preparation method thereof. The compound has strong antibacterial activity and the preparation method thereof Simple, short synthesis time, abundant and versatile raw material sources

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Voriconazole copper nitrate complex with bacteriostatic activity and preparation method thereof
  • Voriconazole copper nitrate complex with bacteriostatic activity and preparation method thereof
  • Voriconazole copper nitrate complex with bacteriostatic activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment one, the synthesis of product 1

[0024] Dissolve voriconazole (FZ) 0.035g (0.1mmol) and 0.02416g (0.1mmol) copper nitrate in a mixture of water and methanol, then transfer the reaction solution to a flask and heat at a reaction temperature of 65 degrees. The reaction solution was cooled to room temperature after 10 minutes of reaction, and transferred into a test tube. After 5 days, blue blocky crystal 1 was obtained. Gained product 1 is determined its molecular structure through single crystal X-ray diffraction analysis, see figure 1 .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a voriconazole copper nitrate complex with bacteriostatic activity and a preparation method thereof. A synthesis method comprises the steps of dissolving voriconazole (FZ for short) and copper nitrate in a certain volume of water and organic solvent, cooling a reaction mixture to room temperature after heating is completed, carrying out filtering and standing so as to separate out a blue target product, and determining the crystal structure of the target product by monocrystalline X-rays; and the chemical formula of the product is [Cu(FZ)2(NO3)2]. Ultraviolet, infrared and antibacterial activities are further researched. The complex has high antibacterial activity to Achromobacter xylosoxidans, Bacillus subtilis, Candida glabrata, Cryptococcus neoformans, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus and the like. The compound can serve as an excellent novel antibacterial agent product.

Description

technical field [0001] The invention belongs to the fields of inorganic chemistry, organic chemistry, biochemistry and medicinal chemistry, and relates to the synthesis method, structure analysis, ultraviolet, infrared and antibacterial activity research of metal complexes. Background technique [0002] The complexes have potential applications in bioactivity, catalysis, and optics. It is worth noting that the structure of the complex is affected by many factors during the self-assembly process (temperature, pH value, metal salt, auxiliary ligand structure, solvent ratio, etc.), therefore, the design and control of synthesizing the target complex is still facing a challenge. Great challenge (X.G.Guo, W.B.Yang, X.Y.Wu, Q.K.Zhang, L.Lin, R.Yu, C.Z.Lu, CrystEngComm, 2013, 15, 3654-3663). Modern medical research shows that copper complexes can produce antibacterial, antiviral, anti-inflammatory, antitumor, enzyme inhibition or chemical nuclease activities, which has attracted m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A01P1/00A01P3/00A61P31/04
CPCC07F1/005A01N55/02
Inventor 汪永涛赵艳明汤桂梅万文珠赵超
Owner QILU UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com