An Optical Tomography Method Based on Adaptive Voxel Subdivision

Abstract

The invention discloses an optical tomographic imaging method based on self-adaptive voxel subdivision. The three-dimensional fluorescence distribution on the surface of a living body is obtained by obtaining the projection data obtained by a multi-modal molecular imaging system and the anatomical structure obtained by 3DMED segmented organs. The obtained three-dimensional Segment the image for adaptive subdivision of voxels; based on the discrete voxel structure of adaptive subdivision and the fluorescence distribution of surface mapping, establish a system equation and solve the objective function to achieve accurate, fast and high-resolution targeting in vivo rate reconstruction. The invention does not need to divide the tissue into tetrahedrons, saves data storage space, overcomes the limitation of the existing tetrahedron finite element reconstruction technology that the tissue must be tetrahedronized before reconstruction and data storage, and can treat irregular Accurate and fast imaging of anatomical structures, adaptive voxel subdivision to more accurately describe tissue boundary information and improve reconstruction accuracy.

Description

technical field [0001] The invention belongs to the field of optical technology, in particular to an optical tomographic imaging method based on adaptive voxel subdivision. Background technique [0002] As an emerging optical imaging technology, optical three-dimensional imaging is to reconstruct living organisms based on accurate light transmission models in biological tissues by fusing multi-angle optical signals measured on the surface of organisms, anatomical structures of organisms, and tissue optical parameter information. The position and intensity distribution information of the target in the body, among which, the accurate description of the light transmission process in the biological tissue and the accurate and fast reconstruction of the target are the basis for the realization of the optical three-dimensional imaging method. In optical three-dimensional imaging technology, excitation fluorescence tomography, diffusion optical tomography and autofluorescence tomog...

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Problems solved by technology

[0004] The purpose of the present invention is to provide an optical tomographic imaging method based on adaptive voxel subdivision, aiming at solving the problem of complex tetrahedral subdivision when the traditional tetrahedron finite element solution is performed on tissue, and the hexahedron voxel processing process on tissue , only a single type of voxelization is performed on the tissue, and the boundary information of the tissue cannot be accurately described

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