Application of epimedium total flavone in intervention of intestinal tract barrier dysfunction

A technology of intestinal barrier function and total flavonoids, applied in the application field of medicine

Inactive Publication Date: 2016-06-08
CHINA THREE GORGES UNIV
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Therefore, AMPK may participate in the regulation of aging process by linking multiple signaling pathway networks

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  • Application of epimedium total flavone in intervention of intestinal tract barrier dysfunction
  • Application of epimedium total flavone in intervention of intestinal tract barrier dysfunction
  • Application of epimedium total flavone in intervention of intestinal tract barrier dysfunction

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Embodiment Construction

[0019] Effects of total flavonoids of Epimedium on the expression of tight junction protein in the jejunum of aging rats

[0020] To determine whether the gut barrier is compromised in aging rats, we detected the expression of claudin-1 and occludin in the jejunum by immunohistochemistry. Such as figure 1 As shown, the expression of claudin-1 and occludin in adult rat gut was evident. In contrast, intestinal claudin-1 and occludin expressions were significantly reduced in aged rats. The results showed that gut barrier function was impaired in aged rats. However, total flavonoids of Epimedium were used to treat the intestinal tract of aging rats, especially the high-dose group increased the expression of both in the small intestine, indicating that total flavonoids of Epimedium could regulate intestinal barrier dysfunction in aging rats.

[0021] Effects of total flavonoids of Epimedium on the activity of AMPK in the jejunum of aging rats

[0022] In order to confirm that t...

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Abstract

The invention relates to application of an epimedium total flavone in intervention of intestinal tract barrier dysfunction, in particular to application of the epimedium total flavone in preparation of medicine for restraining intestinal tract barrier dysfunction. The epimedium total flavone regulates the aging intestinal tract barrier dysfunction through promoting expression of anti-oxidative stress and longevity related signal channels. The promotion of cell tight junction protein expression includes promotion of intestinal duct claudin-1 and occluding expression.

Description

technical field [0001] The invention provides the application of the total flavonoids of Epimedium in pharmacy, in particular the application in the preparation of the medicament for inhibiting the loss of intestinal barrier function. Background technique [0002] A common feature of aging is the gradual loss of cell integrity, which eventually leads to tissue dysfunction and the death of the body, while maintaining the balance of energy metabolism and enhancing stress resistance can prolong the life of the body. Adenylate-activated protein kinase (AMPK) is the main energy sensor for maintaining the homeostasis of energy metabolism in cells, and the activity of AMPK gradually decreases during aging. Recent studies have shown that AMPK can regulate multiple signaling pathways, including enhancing autophagy and anti-stress. Studies have also found that stress resistance factors such as nuclear factor E2-related factor (Nrf2) and longevity signaling pathways such as FoxO3a and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61P1/00A61P39/06
CPCA61K36/296
Inventor 袁丁张长城顿耀艳王婷刘朝奇周志勇赵海霞
Owner CHINA THREE GORGES UNIV
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