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A fungal strain highly expressing huperzine A and its application

A Huperzine A, high-efficiency expression technology, applied in the field of microorganisms, can solve the problems of high cost, difficult to obtain pure optically active compounds, lack of plant resources, etc. Effect

Active Publication Date: 2019-04-23
陕西仁达康健医药生物科技有限公司
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Problems solved by technology

[0005] The purpose of the present invention is to provide a fungal strain that efficiently expresses huperzine A, which solves the bottleneck of plant resource shortage in obtaining huperzine A from plant extraction; and the chemical synthesis steps are cumbersome and expensive, and it is difficult to obtain pure optically active compounds The problem

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  • A fungal strain highly expressing huperzine A and its application
  • A fungal strain highly expressing huperzine A and its application
  • A fungal strain highly expressing huperzine A and its application

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Embodiment Construction

[0021] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0022] The present invention is a fungal strain that efficiently expresses huperzine A, which is isolated from wild Huperziaserrata (Huperziaserrata Huperzaceae, Huperzia genus) endophytic fungi, and belongs to the genus Mucor racemosus ) NSH-D strain, which has genetic stability after 15 generations in the laboratory, and its amino sequence is shown in SEQ ID NO:1.

[0023] The strain has been preserved in China Ordinary Microorganism Culture Collection Center, a preservation unit designated by the State Intellectual Property Office.

[0024] Biological material deposit information:

[0025] Name: Mucor racemosus NSH-D strain

[0026] Deposit number: CGMCC No.12077

[0027] Deposit unit: General Microbiology Center of China Committee for Microorganism Culture Collection (CGMCC)

[0028] Preservation time: January 15, 2016

[0029] Addre...

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Abstract

The invention discloses a fungal strain for efficiently expressing huperzine A, which is isolated from wild Huperzia serrata (Huperzia serrata Huperzia family, Huperzia genus) endophytic fungus and belongs to the genus Mucor (Mucor racemosus) species NSH‑D strain has genetic stability after 15 generations in the laboratory, and its amino sequence is shown in SEQ ID NO: 1. The fungal strains for high-efficiency expression of huperzine A in the present invention are used as biological strains for treating Alzheimer's disease, and their excellent high-efficiency expression genes for producing huperzine A are transferred into other model strains, and more excellent traits, in addition, strains can be further optimized through mutation breeding. The research on it will be of great significance for the industrial production of huperzine A through biosynthesis, the protection of plant resources, the resolution of clinical first-line drug needs, and the reduction of medical expenses for the treatment of Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of microbes, and in particular relates to a fungal strain highly expressing huperzine A, and also relates to the application of the fungal strain. Background technique [0002] Currently, the class of acetylcholinesterase inhibitors dominates the Alzheimer's disease drug market. Huperzine A is a new type of lycopodium monomeric alkaloid isolated from the folk herbal medicine Huperzia serrata. It is a potent and reversible cholinesterase inhibitor with multi-target effects. The inhibitory effect is 3 times that of physostigmine and 30 times that of galantamine, and the peripheral adverse reactions are low. It is one of the clinically preferred drugs for the treatment of Alzheimer's disease. [0003] The development of drugs derived from natural plants has a long history and is full of vitality. Plant extraction to obtain huperzine A is the easiest way, but plant extraction to obtain huperzine A has faced the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14A61K36/06A61P25/28C12R1/785
CPCA61K36/06C12N1/14C12N1/145C12R2001/785
Inventor 韩文霞李伟泽韩忠文贾敏张寒孙静武永红周永强
Owner 陕西仁达康健医药生物科技有限公司
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