Autism detection marker and detection method thereof

A detection method and technology for autism, applied in the field of disease detection, can solve problems such as detection delay or misdiagnosis, and achieve the effect of improving specificity and accuracy

Active Publication Date: 2016-06-22
SHENZHEN UNIV
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Problems solved by technology

[0004] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a detection marker for autism and its detection method, which aims to solve the problem that the existing detection method has certain subjectivity and easily causes detection delay or misdiagnosis

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  • Autism detection marker and detection method thereof
  • Autism detection marker and detection method thereof

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Embodiment 1

[0025] Sera from children with autism and healthy children were collected separately, and high-throughput proteomics methods were used to compare and analyze the serum of children with autism and healthy children. The results were obtained: Compared with the serum of healthy children, 29 serum differential proteins were obtained in the serum of children with autism, of which 11 expressed proteins were up-regulated and 18 expressed proteins were down-regulated, see Table 1 below for details. Then, the enzyme-linked immunosorbent technology was used to detect the 29 differential proteins one by one, or the protein chip technology was used to detect the 29 differential proteins one by one, and the concentration changes of the detected serum differential proteins were determined. Through the method of high-throughput proteomics, the present invention compares and analyzes the serum of children with autism and the serum of healthy children. Compared with the control, 29 serum differ...

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Abstract

The invention discloses an autism detection marker and a detection method thereof. A set of serum differential proteins provided by the invention can be utilized to detect autism. When the serum differential proteins are used for detecting autism, the detection specificity and accuracy can be promoted, and meanwhile, the result is objective, and the autism detection marker is better than a single disease marker. A high-flux proteomics method is adopted for confirming if the serum differential proteins exist in serum; ELISA technique is adopted for detecting these proteins one by one or a protein chip technique is adopted for detecting these proteins at the same time; the concentration change of the detected serum differential proteins can be confirmed. Compared with the present detection method (autism detection table), the detection method provided by the invention has the advantages of high specificity, sensitivity and accuracy.

Description

technical field [0001] The invention relates to the technical field of disease detection, in particular to an autism detection marker and a detection method thereof. Background technique [0002] Autism, also known as autism, is a neurodevelopmental disorder, and its incidence is increasing year by year. Since the etiology and pathogenesis have not yet been elucidated, there are currently no specific therapeutic drugs and specific detection markers, but early detection and early intervention can significantly improve detection and treatment. The current detection of autism is mainly based on scales, clinical symptoms, descriptions of patients or family members, clinical experience of clinicians, etc., which has a certain degree of subjectivity, which may easily cause detection delays or misdiagnosis. [0003] Therefore, the prior art still needs to be improved and developed. Contents of the invention [0004] In view of the above deficiencies in the prior art, the purpos...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N21/76
CPCG01N21/76G01N33/6803G01N2800/28
Inventor 沈立明陈友姣冯承芸
Owner SHENZHEN UNIV
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