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Cosmetic formulation with curative effect on small-area leucoderma and preparation method of cosmetic formulation

A vitiligo, small-area technology, applied in cosmetic preparations, medical preparations containing active ingredients, cosmetics, etc., can solve the problem of no curative effect standard, etc., and achieve a simple process, good treatment and cosmetic effects, and high efficiency. Effect

Inactive Publication Date: 2016-07-06
TIANSHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no uniform efficacy standard in China, and it is difficult to compare the efficacy of various drugs, but long-term use of certain drugs must clearly consider and evaluate their side effects

Method used

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  • Cosmetic formulation with curative effect on small-area leucoderma and preparation method of cosmetic formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, with petrolatum glycerin moisturizer as base, DMF active molecule is mixed with petrolatum glycerin moisturizer to make;

[0029] Preparation method: accurately weigh a certain amount of vaseline and glycerin (the main components of moisturizer are vaseline and glycerin), put them into a clean beaker according to a certain proportion, heat it to make it just melt, and then put the weighed Add DMF into the beaker (the mass ratio of moisturiser and DMF is 7:3 or 3:2), stir constantly, control the temperature, about 300C, when the small white crystals start to volatilize in the beaker, stop heating and continue Stir and allow it to cool naturally to obtain a white paste at last, which can be formulated to contain DMF30% or 40%.

[0030]Mechanism of action: The main ingredient of this formula is DMF, which is a drug capable of destroying diseased skin tissue. The drug containing 30% DMF takes a long time to treat, and a course of treatment generally takes 3 m...

Embodiment 2

[0031] Example 2, Vaseline glycerin moisturizer as the base, DMF active molecules and the Chinese medicine extract extract selected Scutellaria baicalensis 100g, Astragalus 100g, black plum 300g, psoraleae 300g, Ligustrum lucidum 100g, natural copper and zinc each 15g, Ligusticum chuanxiong 100g, 100g of Angelica dahurica, of which 300g of psoralen plus 2000ml of 95% ethanol is prepared; sealed and soaked at room temperature for two weeks, soaked to remove slag, evaporated the ethanol, and collected 200ml of concentrated extract. Using the principle of semi-permeable membrane, the extract and normal saline were placed on both sides of the permeable membrane for 10 minutes, and then the concentration of normal saline was measured. The extract was titrated by continuous injection of drinking water and NaCl to make it isotonic. Shake it at the same time, add saturated NaOH solution dropwise, and adjust the pH to 6.8 with a PHS-type acidity meter (normal skin pH is 5.5 to 7.0). T...

Embodiment 3

[0039] Embodiment 3, Vaseline glycerin moisturizer cream is used as a matrix, DMF active molecules and the Chinese medicine extract extract are prepared by selecting azone 100g, triamcinolone 120g and 75% medical ethanol 2000ml;

[0040] Preparation method: Soak azone and triamcinolone in 75% ethanol for 2 weeks, filter to remove slag, and obtain soaking liquid, add appropriate amount of spices, preservatives, toner, thickener, volatile oil to make it Become a paste, put it into a clean plastic bottle, and set aside.

[0041] Mechanism of action: As a corticosteroid drug, it can stabilize intracellular lysosome membranes and prevent enzymes in lysosomes from damaging melanocytes. Azone can increase the penetration of drugs into the skin and promote the absorption of drugs. .

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Abstract

The invention discloses a cosmetic formulation with a curative effect on small-area leucoderma and a preparation method of the cosmetic formulation.The cosmetic formulation comprises a composition of DMF active molecules, Vaseline and glycerin moisturizing cream or a composition of the DMF active molecules, Vaseline and glycerin moisturizing cream and traditional Chinese medicine extract, wherein the content of the DMF active molecules is 10-50%, and a ratio of the Vaseline to the glycerin to the traditional Chinese medicine extract is 5:1:3.The preparation method includes: step one, raw material selection; step two, heating and stirring; step three, cooling; step four, addition of the traditional Chinese medicine extract.The cosmetic formulation is implemented according to a melting and coating process to obtain a pharmacological cosmetic free of toxins or side effects; the technical process is simple, and effective ingredients and pharmacological functions are undamaged and unaffected; the cosmetic has excellent curative and beautifying effects.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a cosmetic formula with small-area vitiligo curative effect and a preparation method thereof. Background technique [0002] Vitiligo is an acquired hypopigmentation disease, children are not congenital diseases. Not contagious. The pathogenesis of vitiligo is not very clear at present, but there are many theories, such as genetics, autoimmunity, melanocyte self-injury theory, neurochemical theory, etc., and current research tends to autoimmune theory. At present, there is no theory that can explain and evaluate the pathogenesis of this disease, but there are many clinical and laboratory evidences that prove that it is related to autoimmunity. At present, there is no effective radical cure method. Although the depigmentation of most patients no longer expands after treatment, it is difficult to subside, especially in the face and neck, which affects beauty and makes patients feel inferi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/63A61K8/49A61K8/34A61K8/31A61K8/19A61K8/27A61Q19/00A61P17/00A61K8/9789
CPCA61K8/19A61K8/27A61K8/31A61K8/345A61K8/49A61K8/63A61K8/97A61K31/4748A61K31/573A61K33/26A61K33/30A61K33/34A61K36/185A61K36/232A61K36/234A61K36/238A61K36/268A61K36/28A61K36/286A61K36/31A61K36/39A61K36/481A61K36/484A61K36/487A61K36/539A61K36/61A61K36/638A61K36/65A61K36/704A61K36/71A61K36/736A61K36/744A61K36/75A61K36/9066A61Q19/00A61Q19/005A61K2300/00
Inventor 雷新有张宗舟白小华吕玲玲袁焜
Owner TIANSHUI NORMAL UNIV
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