Process for preparing a mixture of a cellulose derivative and a liquid diluent
A technology of cellulose derivatives and liquid diluents, which is applied in the direction of cellulose derivative coatings, microsphere preparation, microcapsule preparations, etc., and can solve the problems of cost increase, expensive, long time, etc.
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[0042] All parts and percentages are by weight unless otherwise mentioned. In the examples, the following test procedure was used.
[0043] BET method of hydroxypropyl methylcellulose (HPMC)
[0044] The specific surface area of the cellulose derivative particles (specifically, HPMC) was measured by the BET method. The BET method is performed according to DIN9277:2003-05. After complete drying (7 hours at 105° C.), the krypton BET was measured using a microbiology ASAP2020.
[0045] Viscosity of HPMC
[0046] The viscosity of the HPMC samples was measured as a 2.0% by weight aqueous solution at 20°C. A 2.0% by weight aqueous solution of HPMC was prepared according to "United States Pharmacopoeia" (USP35, "Hypromellose", pp. 3467-3469), followed by erbroxol according to DIN51562-1:1999-01 (January 1999). German viscosity measurement.
[0047] LEFI and EQPC of HPMC
[0048] The particle size and shape of the cellulose derivative particles are determined by a high-...
example 2
[0060] HPMC having 29.2% methoxyl groups, 6.3% hydroxypropoxyl groups, and a viscosity of about 4000 mPa·s measured as a 2.0% aqueous solution at 20° C. was used as a starting material for manufacturing the HPMC particles of Example 2. The manufacture of HPMC particles involved mixing HPMC and water, grinding and drying the mixture in an impact mill and deagglomerating the resulting HPMC particles as described below.
[0061] HPMC at a temperature of 20°C was continuously fed at a feed rate of 20 kg / h into a commercially available continuous compounder with heating and cooling jackets. Water at a temperature of 5°C was continuously added to the compounder to achieve a moisture of 73% based on the total weight of the wet HPMC. The wet HPMC product was continuously transported via a conveyor belt to the mill feed unit (Altenburger Maschinen Jaeckering GmbH, Hamm, Germany). The mill feed unit was a vessel equipped with a vessel agitator having paddles and a single screw. The bo...
example 1
[0074] The HPMCs of Examples 1 and 2 have very similar specific surface areas and similar degassing properties, but they have been fabricated using different means and although the morphologies of the HPMC particles of Examples 1 and 2 are very different. The median LEFI and EQPC in the HPMCs of Example 1 were about twice as high as the median LEFI and EQPC in the HPMCs of Example 2.
[0075] The specific surface area of the HPMC of Comparative Examples A and B exceeds 0.20m 2 / g. They all have similar outgassing properties, but the particles of the granulated HPMC of Comparative Example B are much coarser than the particles of HPMC of Comparative Example A as evidenced by the much higher median EQPC.
[0076] The aqueous solution of HPMC of Example 2 exhibited significantly faster degassing than the aqueous solution of HPMC of Comparative Example B. The specific surface area of the HPMC of example 2 is less than 0.20m 2 / g, while the specific surface area of the HPMC...
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