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Use of ethanol extract of undaria pinnatifida in preparation of composition for treating or preventing influenza A virus infection

A technology of influenza virus infection and ethanol extraction, which can be used in drug combinations, antiviral agents, respiratory diseases, etc., and can solve problems such as few in-depth discussions

Active Publication Date: 2016-07-13
NATIONAL TAIWAN OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most literatures report the antiviral activity of sulfated polysaccharides in water extracts of wakame, but there are few in-depth studies on the alcohol extracts of wakame

Method used

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  • Use of ethanol extract of undaria pinnatifida in preparation of composition for treating or preventing influenza A virus infection
  • Use of ethanol extract of undaria pinnatifida in preparation of composition for treating or preventing influenza A virus infection
  • Use of ethanol extract of undaria pinnatifida in preparation of composition for treating or preventing influenza A virus infection

Examples

Experimental program
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Embodiment

[0056] 1. Materials and methods

[0057] 1.1 Extraction of Undaria pinnatifida and analysis of its antioxidant capacity

[0058] 1.1.1 Ethanol extract of wakame

[0059] Undaria pinnatifida was purchased from Heping Island, Keelung, Taiwan. Grind dried wakame into powder, take 100g wakame powder (g) and absolute alcohol volume (ml) in a ratio of 1:6 (w / v), and keep it away from light at room temperature Stirring was continued for one day, and then the solid part was removed by suction filtration, and the liquid obtained by suction filtration was concentrated under reduced pressure to remove the solvent and then became the ethanol extract of wakame (Parketal., 2010, FoodChemToxicol49: 727-733).

[0060] 1.1.2 Wakame water extract

[0061] Grind the dried wakame into powder, mix (w / v) 100g wakame powder (g) with deionized water volume (ml) at a ratio of 1:10, extract at 100°C for 1 hour, and filter with air Add four times the volume of absolute alcohol to the obtained wakame ...

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Abstract

The invention discloses a use of ethanol extract of undaria pinnatifida in preparation of composition for treating or preventing influenza A virus infection.

Description

technical field [0001] The invention relates to the application of ethanol extract of wakame to treat or prevent type A influenza virus infection. Background technique [0002] Influenza Avirus (IAV), a member of the Myxoviridae family, is an enveloped, negative-strand RNA virus containing an eight-segment genome. Type A influenza has caused several pandemics among humans in the past, namely 1918, 1957, 1968 and 1977, among which the 1918 pandemic caused 40 million deaths within one year, the fatality rate Nearly 50%, the most lethal infection for influenza virus (PaleseP (2004) NatMed 10:S82-87). The latest influenza A outbreak also caused 300,000 infections around the world (Wu et al., (2012) PLoS One7:e49856). [0003] Once the influenza virus infects the respiratory epithelial cells, the immune system will be activated rapidly. Innate immunity occurs first, and the single-stranded RNA of the virus is regulated by Toll-like receptor 7 (Toll-likereceptor7, TLR7), TLR8 a...

Claims

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Application Information

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IPC IPC(8): A61K36/03A61P31/16A61P29/00A61P11/00
Inventor 吴彰哲邱雅凰王昱权
Owner NATIONAL TAIWAN OCEAN UNIVERSITY