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Application of n-butanol fraction of ethanol extract of borreria stricta raw material in preparation of sperm-producing and yang strengthening drug

A technology for producing essence, strengthening yang, and enriching flowers and plants. It is applied in the application field of medicine, which can solve the problems of large number of medicinal herbs, unfavorable protection of traditional Chinese medicine plant varieties, and high cost, and achieve the effect of improving reproductive ability.

Inactive Publication Date: 2016-07-13
YANTAI HUAWEN XINXIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there are currently many prescriptions that can invigorate the kidney and strengthen yang, and improve male sexual dysfunction, their prescriptions have a large number of Chinese medicine flavors, high cost, and are not conducive to the protection of Chinese medicinal plant varieties.

Method used

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  • Application of n-butanol fraction of ethanol extract of borreria stricta raw material in preparation of sperm-producing and yang strengthening drug
  • Application of n-butanol fraction of ethanol extract of borreria stricta raw material in preparation of sperm-producing and yang strengthening drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of the n-butanol part extract of fenghuacao of embodiment 1

[0016] 500g of Fenghuacao raw material is crushed with a FW135 traditional Chinese medicine grinder, placed in an extraction device with a round bottom flask, extracted with 4L of ethanol solution with a concentration of 95% (v / v) for 2 hours, filtered to obtain an alcohol extract, and repeated 2 times, combined ethanol extracts, concentrated to dryness under reduced pressure to obtain crude extracts, dissolved into a suspension with 1.6L pure water, extracted 2 times with 1.6L n-butanol to obtain n-butanol extracts, recovered n-butanol After alcohol, continue to concentrate under reduced pressure to form a thick paste, freeze-dry, pulverize into fine powder, and pass through a 100-mesh sieve to obtain the n-butanol part of the alcohol extract of Fenghuacao.

Embodiment 2

[0017] Example 2 Experimental Study on Improving Spermatogenesis in Mice with Deficiency of Kidney Essence by Fenghuacao Extract

[0018] Healthy sexually mature Kunming mice with a body mass of (24±2) g. Select female mice in estrus, inject 0.05 mL of contraceptive needle No. 1 subcutaneously into each female mouse, and check the degree of keratinocytes with vaginal smears to confirm. Each male mouse was co-caged with two estrus female mice, and the male mice in the female cages with vaginal suppositories were taken out the next day as experimental mice. Take 24 screened male mice, and each male mouse is in the same cage with 5 estrous female mice, and pay attention to changing the female mice every day to induce sexual immorality, which lasts for 8 weeks. Twenty male mice with room labor were randomly divided into a control group and a treatment group, 10 in each group. The control group was given 0.3 mL of distilled water for intragastric administration, and the treatment...

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Abstract

The invention discloses an application of an n-butanol fraction of an ethanol extract of a borreria stricta raw material in preparation of a sperm-producing and yang strengthening drug and relates to the technical field of medicine. The borreria stricta raw material is the overground part of grass plant borreria stricta. The n-butanol fraction of the ethanol extract of the borreria stricta raw material has functions of tonifying the kidney to produce sperms and regulating yin and yang, can improve the reproductive capacity of a male patient and is suitable for a male infertile patient with kidney-essence deficiency caused by intemperance in sexual life.

Description

[0001] This application is a divisional case of the invention patent application proposed by the applicant Cui Yinfang (the name of the invention is: a pharmaceutical composition for promoting spermatogenesis and impotence and its preparation method, the application number is 2014104808099, and the application date is September 19, 2014) Application. technical field [0002] The invention belongs to the technical field of plant extraction, and in particular relates to the application of the n-butanol part of the ethanol extract of the raw material of Fenghuacao in the preparation of medicines for spermatogenic and aphrodisiac. Background technique [0003] Sex life after marriage is a physiological need of men and women. Normal sex life should be 2-3 times a week. Specifically, the standard should be that there is no fatigue and discomfort the next day after sex. If you feel weak all over the body, lack of energy, dizziness, weakness of limbs, palpitations, shortness of brea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P15/10
CPCA61K36/74A61K2236/33A61K2236/333A61K2236/51
Inventor 刘学键
Owner YANTAI HUAWEN XINXIN PHARMA CO LTD
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