Manufacturing method of implantable artificial retina ceramic package

Abstract

The invention discloses a manufacturing method of an implantable artificial retina ceramic packaging body. The method comprises the following steps: 1, providing a ceramic substrate with at least one through hole; 2, filling the through hole with a conductive slurry with biological compatibility, and sintering both the conductive slurry and the ceramic substrate; 3, forming conductive welding discs with biological compatibility on the upper surface and the lower surface of the conductive slurry exposed outside the through hole after sintering in the second step; 4, arranging a metal ring with biological compatibility on the ceramic substrate, wherein the metal ring surrounds all the conducive welding discs disposed at the same side of the ceramic substrate; and 5, arranging a metal cover with biological compatibility on the metal ring to form an enclosed space accommodating a circuit board. According to the invention, the packaging body manufactured by use of the method is high in airtightness, prevents a human body from damage caused by penetration of incompatible substances in the packaging body into a body fluid and is good in biological compatibility. The difficulty in a manufacturing process is quite low, and the method is easier to promote.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a method for manufacturing an implantable artificial retina ceramic package. Background technique [0002] Vision provides an important way for humans to understand the world, and more than 70% of external information needs to be conveyed through vision. About 10 million people around the world are blind due to the loss of photoreceptor cells in the retina, but most of the patients with damaged photoreceptor cells have the rest of the visual pathway still intact. Currently, there is no clinical treatment for this blinding disease. In order to save this special patient, we use the principle similar to the clinically successful cochlear implant, and use the artificial retina to restore part of the patient's visual function through functional restoration, which has become a very promising treatment method. In the past ten years, the design and development of an artificial ret...

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Problems solved by technology

[0009] However, this sintering method is difficult, and it is difficult to ensure that all platinum wires are compressed after sintering, that is, it is difficult to meet the airtightness requirements

If the airtightness is insufficient, the body fluid in the human eye and the non-biocompatible chip environment in the package may permeate and diffuse with each other, and incompatible substances in the package will penetrate into the body fluid and cause harm to the human body

[0010] In addition, this sintering method needs to continuously inject hydrogen into the sintering furnace for reduction, which is prone to explosion and high risk. It requires professional equipment and professionals to operate, so it is difficult to promote this sintering method

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