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Novel Mogrol derivative monomer

A technology of Mogrosin and its derivatives, applied in the field of medicine

Inactive Publication Date: 2016-07-20
SHENZHEN YINUO BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no patents and literature reports to generate monk fruit alcohol derivative monomers (3) and monk fruit alcohol derivative monomers (4) under specific conditions through mogroscarpol (2), nor are there any patents and literature reports Alcohol Derivative Monomer(4)

Method used

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  • Novel Mogrol derivative monomer
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  • Novel Mogrol derivative monomer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1: Preparation of Mogrosanol Derivatives Monomers (3) and (4) from the Extract of 98% Mogrosin Total Saponins

[0056] Add 50g of Luo Han Guo extract (98% of the total saponins of Luo Han Guo, containing 55% of Mogroside V, purchased from Guilin Laiyin Biotechnology Co., Ltd.) to 250 mL of ethanol aqueous solution (the volume ratio of ethanol and water is 1:1) (prepared with Hydrochloric acid adjusted to a pH value of 3.0), stirred and dissolved in the reactor, then heated to 120 ° C for 2 hours, cooled to room temperature 25 ° C, the reaction solution was neutralized to a pH value of 7 with 1M NaOH lye, and in Distill the ethanol as much as possible at 90-95°C, add 200mL of distilled water to the remaining concentrated solution, stir thoroughly, cool and let it stand, separate and discard the upper water layer to obtain a brown extract; use 100mL, 50mL, and 50mL of acetic acid respectively Extract the brown extract with ethyl ester for 3 times, combine the 3 ex...

Embodiment 2

[0058] Example 2: Preparation of Mogrosanol Derivative Monomers (3) and (4) from the Extract of 95% Mogrosin Total Saponins

[0059] Add 50g of Luo Han Guo extract (95% of the total saponins of Luo Han Guo, containing 45% of mogroside V, purchased from Guilin Laiyin Biotechnology Co., Ltd.) into 250 mL of methanol aqueous solution (the volume ratio of methanol and water is 3:2) (pre-used Sulfuric acid is adjusted to a pH value of 2.8), stirred and dissolved in the reactor, and then heated to 120°C for 2 hours, cooled to room temperature, and the reaction solution is neutralized with 1M KOH lye to a pH value of 7. Distill the methanol as much as possible at 95°C, add 200mL of distilled water to the remaining concentrated solution, stir thoroughly, cool and let it stand, separate and discard the upper water layer to obtain a brown extract; use 100mL, 50mL, and 50mL ethyl acetate respectively Extract the coffee-colored extract 3 times, combine the 3 extracts, concentrate with a r...

Embodiment 3

[0060] Example 3: Preparation of mogrosanol derivative monomers (3) and (4) from the extract of 90% total saponins of Monk Fruit

[0061] Add 50g of Luo Han Guo extract (90% of Luo Han Guo total saponins, containing 40% mogroside V, purchased from Guilin Laiyin Biotechnology Co., Ltd.) into 250 mL of n-propanol aqueous solution (the volume ratio of n-propanol and water is 2:3) (Adjust the pH value to 3.2 with formic acid in advance, stir and dissolve in the reaction kettle, then heat up to 120 ° C for 2 hours, after cooling to room temperature, the reaction solution is neutralized with 1M NaOH lye to a pH value of 7, in Distill out n-propanol as much as possible at 90-95°C, add 200mL of distilled water to the remaining concentrated solution, stir thoroughly, cool and let it stand, separate and discard the upper water layer to obtain a brown extract; use 100mL, 50mL, Extract the brown extract with 50mL ethyl acetate for 3 times, combine the 3 extracts, concentrate with a rotary...

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Abstract

The invention provides a novel Mogrol derivative monomer (4). The novel Mogrol derivative monomer (4) can be prepared into drugs for treating and / or preventing different cancers and / or tumors, can also be prepared into healthy products for regulating immunity and / or improving microcirculation and / or improving quality of life, crucially is applied to the treatment of malignant tumors and has a broad application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a novel mogrosanol derivative monomer. Background technique [0002] Cancer is the second largest disease in the world that ravages human life, and its mortality rate is second only to cardiovascular and cerebrovascular diseases, and it is one of the most important factors of human death. The latest edition of the "World Cancer Report" in charge of the International Cancer Research Center (IARC), the official cancer agency under the WHO, predicts that global cancer cases will show a rapid increase, from 14 million in 2012 to 19 million people in 2025, will reach 24 million people by 2035. The report also shows that in 2012, nearly half of the new cancer cases in the world occurred in Asia, most of which were in China, and China ranked first in the number of new cancer cases. In 2012, there were 3.07 million new cancer patients and about 2.2 million deaths in China, accounting for 21.9% ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00A61K31/575A61P35/00A61P35/02
CPCA61K31/575C07J9/00
Inventor 余佩华邓跃敏钟牧源
Owner SHENZHEN YINUO BIOPHARM CO LTD