Method for producing Rakicidins compounds by virtue of marine micromonospora fermentation

A compound and fermenter technology, applied in the field of industrial microorganisms and biopharmaceuticals, can solve the problems of low fermentation titer and inability to achieve industrialized production, and achieve the effect of meeting the needs of industrialization
CN105779348AActive Publication Date: 2016-07-20FUJIAN INST OF MICROBIOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUJIAN INST OF MICROBIOLOGY
Publication Date
2016-07-20

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Abstract

The invention relates to the technical field of industrial microorganisms and the field of biological medicines, and in particular relates to a method for producing Rakicidins compounds by virtue of marine micromonospora fermentation. The method is characterized by comprising the following steps: performing solid slant culture on micromonospora which is collected in the China General Microbiological Culture Collection Center (CGMCC) and has a collection number of CGMCC NO. 12132, performing shake flask seed culture, seeding tank culture and fermentation tank fermentation culture, and performing after-treatment to obtain the compounds, wherein amino acid is replenished in the fermentation initial stage of a fermentation tank. The fermentation method provided by the invention is simple in operation and low in cost and can be used for realizing industrial large-scale production, and the highest total fermentation titer reaches about 600mg / L.
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Description

technical field

[0001] The invention relates to the technical field of industrial microbes and the field of biomedicine, in particular to a method for fermenting Micromonospora marine to produce Rakicidins compounds. Background technique

[0002] The anti-cancer drug market has grown rapidly in recent years. In 2014, the global sales of anti-cancer drug market reached 100 billion US dollars; by 2018, the anti-cancer drug market will reach 147 billion US dollars, with a compound growth rate of 11.6%. The research and development of anti-cancer drugs will make huge profits . Hypoxia is one of the characteristics of malignant solid tumors. Hypoxia is closely related to tumor angiogenesis, invasion and metastasis, resistance to radiotherapy and chemotherapy, and poor prognosis. Hypoxia-inducible factor 1 (hypoxia-inducible factor 1, HIF-1) is the most critical nuclear transcriptional regulator in the regulation of hypoxia effects. HIF-1 is selectively and continuously highly e...

Claims

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