Micro-structure body and preparation method thereof

A technology of microstructures and microneedles, which is applied in the fields of biomedicine and medical cosmetology, and can solve problems such as unsatisfactory needs

Inactive Publication Date: 2016-07-27
李媚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These solutions all disclose highly consistent microstructures, but ca...

Method used

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  • Micro-structure body and preparation method thereof
  • Micro-structure body and preparation method thereof
  • Micro-structure body and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of microstructure

[0029] Take 1.5g of hyaluronic acid and 0.5g of sodium carboxymethylcellulose dissolved in 50ml of water for injection to form a gel, adjust the pH to 7.0, and put the gel into the delivery system.

[0030] Input the microstructure instruction of printing conical microneedles of consistent height through the computer to the control system of the 3D printer. The gel was delivered to the nozzle of the print head, printed into substrate and microneedles through the nozzle, dried naturally for 12 hours, and finally sterilized by ethylene oxide. The performance parameters of the microstructure prepared by this method are shown in Table 1.

[0031] Table 1.

[0032]

Embodiment 2

[0033] Embodiment 2: Preparation of microstructure

[0034] Take 2g of hyaluronic acid and 0.1g of collagen and dissolve 80ml of water for injection to form a gel, adjust the pH to 7.2, and put the gel into the delivery system.

[0035] Input the instruction of printing conical microneedles of different heights to the control system of the 3D printer through the computer. The gel is transported to the nozzle of the print head, printed into substrates and microneedles through the nozzle, dried at 95°C for 5s, and finally sterilized with ethylene oxide. The performance parameters of the microstructure prepared by this method are shown in Table 2.

[0036] Table 2.

[0037]

Embodiment 3

[0038] Embodiment three: preparation of microstructure

[0039] Add 1g of hyaluronic acid to 15ml of water, add BDDE according to 0.001% (W / W) of hyaluronic acid, cross-link under alkaline conditions, swell with neutral physiological isotonic phosphate buffer to form a gel, and then gel Mix 2% (W / W) polylactic acid-glycolic acid into the gel, adjust the pH to 7.0, and load the gel into the delivery system.

[0040]Input the microstructure command of printing cylindrical microneedles of consistent height to the control system of the 3D printer through the computer, the control system sends out the command, the print head starts after receiving the command through WIFI and the feeding system is turned on, and the feeding system sends the gel Delivered to the nozzles of the print head, the substrate and microneedles are printed through the nozzles, dried at 35°C for 4 hours, and finally sterilized by irradiation at 60°C. The performance parameters of the microstructure prepared ...

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Abstract

The invention relates to a micro-structure body and a preparation method thereof. The micro-structure body is mainly composed of a microneedle and a substrate where the microneedle is vertically arranged. The preparation method comprises the steps of providing gel of the substrate and the microneedle; printing the substrate through a 3D printer, and printing the microneedle on the substrate; performing sterilization. The micro-structure body has the advantages of achieving controlled degradation and sustained release, being easy to prepare, meeting the individualized requirement and being applicable to the fields of biological medicine and medical cosmetology.

Description

technical field [0001] The invention relates to a microstructure and a preparation method thereof, in particular to a microstructure prepared by 3D printing technology and inserted into human skin, which can be applied to the fields of biomedicine and medical cosmetology. Background technique [0002] At present, oral administration and injection are the most commonly used methods of drug delivery in the field of biomedicine and medical cosmetology, but the drug is not effective after oral administration through stomach acid, and the injection needle will stimulate the deep nerve cells of the skin and easily cause pain to the human body. In recent years, people have studied biodegradable microstructures with medicinal ingredients as a solution to the shortcomings of transdermal drug delivery in the fields of biomedicine and medical cosmetology. Application numbers CN201180067944.5 and CN201380025634.6 respectively provide microstructure manufacturing method, the patent appli...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0053
Inventor 李媚
Owner 李媚
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