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A kind of preparation method of coumarin compound

A technology of coumarins and complexes, applied in the field of biochemistry, can solve problems such as loss of activity and lack of solutions

Inactive Publication Date: 2018-07-06
BEIJING INSTITUTE OF PETROCHEMICAL TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] As an important bioactive component, 7H4MC may react and lose its activity during the process of drug processing and utilization, but there is no effective solution in the prior art

Method used

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  • A kind of preparation method of coumarin compound
  • A kind of preparation method of coumarin compound
  • A kind of preparation method of coumarin compound

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Embodiment Construction

[0026] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0027] Embodiments of the present invention will be further described in detail below in conjunction with the accompanying drawings, as figure 1 Shown is a schematic flow chart of the preparation method of the coumarin complex provided by the embodiment of the present invention, and the preparation method includes:

[0028] Step 11: First prepare nitrate-type layered gadolinium hydroxide NO by homogeneous precipitation method 3 -LGdH as precursor;...

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Abstract

The invention discloses a preparation method of a coumarins complex. The preparation method comprises the following steps of firstly, preparing a nitrate radical type layered gadolinium hydroxide (NO3-LGdH) as a precursor by a uniform settlement method; then, performing ion exchange reaction on 7-hydroxy-4-methylcoumarin (7H4MC), removing proton, and inserting into an LGdH layer of the precursor, so as to obtain the 7H4MC-LGdH complex. The coumarins complex prepared by the preparation method has the advantages that the 7-hydroxy-4-methylcoumarin molecules can be effectively protected, a pure blue emitting is presented, and the 7-hydroxy-4-methylcoumarin is applied to the fields of magnetic resonance imaging, light emitting display devices and the like.

Description

technical field [0001] The invention relates to the technical field of biochemistry, in particular to a preparation method of a coumarin complex. Background technique [0002] Coumarin compounds have a benzopyrone core, are widely distributed in nature, and have various biological activities such as antibacterial, anti-inflammatory, anticoagulant, anticancer and antitumor. The basic structure of coumarin has no fluorescence, but After introducing an electron-donating group at the 7-position and an electron-withdrawing group at the 3 or 4-position, a push-pull electron system is formed to obtain a strong fluorescent substance. Coumarin derivatives generally have suitable maximum excitation and emission wavelengths, large Stokes shifts, and high fluorescence quantum yields, and are often used in the research of fluorescent probes. As a kind of coumarin derivatives, 7- Hydroxy-4-methylcoumarin (7H4MC) has biological activities such as analgesia, antibacterial, anti-tuberculosi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/06C09K11/02
CPCC09K11/02C09K11/06C09K2211/1088
Inventor 谷庆阳段菲陈稳
Owner BEIJING INSTITUTE OF PETROCHEMICAL TECHNOLOGY