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A gentamicin-degrading fungus and its application

A technology of gentamicin and fungi, which is applied to the fungus that degrades gentamicin and its application field, which can solve the problems of screening of aminoglycoside antibiotic-degrading bacteria that have not yet been found, and achieve the effect of reducing adverse effects

Active Publication Date: 2019-04-05
INST OF AGRI RESOURCES & REGIONAL PLANNING CHINESE ACADEMY OF AGRI SCI +1
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  • Claims
  • Application Information

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Problems solved by technology

However, according to literature and patent searches, at present, most of the studies are on antibiotic-degrading bacteria such as tetracyclines, sulfonamides, β-lactams, fluoroquinolones and macrolides, and no screening of aminoglycoside antibiotic-degrading bacteria has been found.

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  • A gentamicin-degrading fungus and its application
  • A gentamicin-degrading fungus and its application
  • A gentamicin-degrading fungus and its application

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experiment example

[0046] 1. Screening of target bacteria

[0047] ①Purification of fungus from medicinal residues by coating plate method: pick appropriate amount of medicinal residues with a pick and inoculate them on MB medium, and culture them in a constant temperature incubator at 30°C for 7 days.

[0048] After 7 days, pick fungi with different shapes and spot them on the MMB medium for purification. After cultivating in a constant temperature incubator at 30°C for 7 days, repeat the process. After obtaining the purified fungi, transfer them to the slant MMB medium. Store in a refrigerator at 4°C.

[0049] ②Evaluation of gentamicin degradation ability: inoculate the fungi preserved in step ① into 250mL Erlenmeyer flasks containing 100mL 1 / 10LPD and inorganic salt medium MSM, and add gentamicin standard to make the content 100mg / L, cultivated in a constant temperature shaker (30°C, 150rpm) as the experimental group, while using the culture medium not inoculated with fungi as the blank con...

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Abstract

A strain of fungus (Aspergillus terreus FZC3), whose preservation number is CGMCC No.12072, can be used to degrade gentamicin by inoculating the fungus into a system containing gentamicin and cultivating it to degrade gentamicin Mycin. By cultivating the fungus of the present invention, the gentamicin in the environment can be removed, used for treating pharmaceutical waste, and reducing the harm of the gentamicin to the environment, human beings and animals.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a fungus for degrading gentamicin and its application. Background technique [0002] Antibiotics are a class of secondary metabolites produced by microorganisms (including bacteria, fungi, and actinomycetes) that have anti-pathogen or other activities, and can interfere with the developmental functions of other living cells. As antibacterial or bactericidal drugs, antibiotics have been widely used in the treatment of human diseases, livestock and aquaculture, etc., mainly including tetracyclines, sulfonamides, β-lactams, fluoroquinolones, aminoglycosides and large cyclic lactones, etc. my country is a big country in the production and use of antibiotics, with an annual production of 210,000 tons of antibiotics and a usage of 189,000 tons, of which veterinary antibiotics account for more than half of the usage. Studies have found that after organisms ingest a large amount of antibio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14A62D3/02C02F3/34C12R1/66A62D101/28C02F101/38
CPCA62D3/02A62D2101/28C02F3/347C02F2101/38C12N1/145C12R2001/66
Inventor 李兆君刘元望葛祥斌郝金海胡海燕冯瑶杜德维章程王莉莉马金凤
Owner INST OF AGRI RESOURCES & REGIONAL PLANNING CHINESE ACADEMY OF AGRI SCI
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