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A kind of medical functional chitosan dressing and preparation method thereof

A water-soluble chitosan and chitosan technology, applied in the field of skin care medical devices, can solve the problems of chitosan's antibacterial effect and poor water solubility, so as to promote wound healing and growth, Wide range of applications, the effect of reducing scar formation

Active Publication Date: 2019-08-23
GUANGZHOU RHFAY BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most chitosan gels have poor water solubility due to the selection of chitosan raw materials, and the antibacterial effect of chitosan cannot be well exerted, and antibacterial agents need to be added during the preparation process.

Method used

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  • A kind of medical functional chitosan dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The medical functional chitosan dressing of the present embodiment consists of the following components: 0.5 g of water-soluble chitosan, 0.8 g of carbomer, 1 g of glycerin, 0.2 g of sodium benzoate, 0.6 g of triethanolamine, and 96.9 g of purified water. Its preparation method is as follows:

[0027] 1. Preparation of water-soluble chitosan: use 10 grams of high deacetylation degree chitosan, add 10-30mL of 0.1-1mol / L acetic acid, add wheat germ lipase dropwise at 10U-60U, then add 10-20 grams Tetraose and sucrose, heated to 40°C-60°C, stirred and reacted for 8-16 hours. After adding 200-300ml of absolute ethanol to produce flocs, centrifuge to precipitate, discard the supernatant, filter the substrate, and freeze-dry to obtain water-soluble chitosan.

[0028] 2. Preparation of carbomer masterbatch: add 50% purified water according to the formula amount, evenly add carbomer in the formula amount, stir at 30°C-40°C for 1-2 hours, and swell for 24-48 hours to obtain car...

Embodiment 2

[0031] [Example 2] The preparation method of the medical functional chitosan dressing of the present embodiment is the same as that of Example 1, and it consists of the following components: water-soluble chitosan 1g, carbomer 0.6g, glycerin 3g, sodium benzoate 0.3g, Triethanolamine 0.5g, purified water 94.6g.

Embodiment 3

[0032] [Example 3] The preparation method of the medical functional chitosan dressing of the present embodiment is the same as in Example 1, and it consists of the following components: 1.5 g of water-soluble chitosan, 0.4 g of carbomer, 5 g of glycerin, and 0.5 g of sodium benzoate , 0.2 g of triethanolamine, and 92.4 g of purified water.

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Abstract

The invention discloses a medical functional chitosan dressing, which is composed of the following components in mass fraction: carbomer 0.4-0.8%, water-soluble chitosan 0.5-1.5%, glycerin 1-5%, sodium benzoate 0.2- 0.5%, triethanolamine 0.2-0.6%, purified water 90-98%. The medical functional chitosan dressing of the present invention uses chitosan with good water solubility as a material to achieve anti-inflammation and anti-bacteria, absorb inflammatory tissue exudate, promote wound healing and growth, and reduce scar formation.

Description

technical field [0001] The invention relates to the field of medical devices for skin care, and specifically discloses a medical functional chitosan dressing and a preparation method thereof. Background technique [0002] Chitosan is a natural polymer. It is the only positively charged animal cellulose found so far in nature. There are unsaturated cationic groups in the molecule, and it has a strong adsorption effect on various negatively charged harmful substances such as bacteria, fungi and viruses, such as gold Staphylococcus aureus, Escherichia coli, Candida albicans, etc. The mechanism is that the amino group is positively charged, which can adhere to the bacteria and interfere with the metabolism of the outer wall of the bacteria; the positive charge on the surface of chitosan interacts with the receptors of amino acid residues on the surface of red blood cells to reduce the negative charge. Direct adhesion and aggregation can achieve good hemostatic and analgesic ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61L26/00A61K9/06A61K47/32A61P15/00A61P31/04A61P31/10A61P17/02
CPCA61K9/06A61K31/722A61K47/32A61L26/0014A61L26/0023A61L26/0066A61L2300/232A61L2300/404A61L2300/412C08L5/08C08L33/02
Inventor 吴国锋李有生
Owner GUANGZHOU RHFAY BIOTECH CO LTD
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