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Detection apparatus and detection method for drug effect of anti-cancer drug vincristine

A technology of vincristine and detection device, which is applied in the direction of electrochemical variables of materials, etc., can solve problems such as toxic reactions, physical injury of patients, and inability to achieve therapeutic effects, and achieve the effect of increasing accuracy and ensuring safety.

Active Publication Date: 2016-08-17
HANGZHOU RED CROSS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no clinical data to refer to the efficacy of new anti-cancer drugs. In the initial use, it is entirely dependent on the doctor's exploration and judgment. If the dose is insufficient, the therapeutic effect will not be achieved; Patient's bodily harm

Method used

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  • Detection apparatus and detection method for drug effect of anti-cancer drug vincristine
  • Detection apparatus and detection method for drug effect of anti-cancer drug vincristine
  • Detection apparatus and detection method for drug effect of anti-cancer drug vincristine

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Embodiment Construction

[0049] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0050] Such as figure 1 , figure 2 , image 3 The shown embodiment is a kind of drug efficacy testing device for the anticancer drug vincristine, comprising an electrochemical workstation 1, a flow cell 2, three substrates 3 arranged radially in the flow cell, and each The electrode chip 4 on the block substrate, the first solution hanging bottle 5 that fills the cleaning solution, the second solution hanging bottle 6 that fills the vincristine solution, the first micropump 7 connected with the first solution hanging bottle, and the second solution hanging bottle 7 connected with the first solution hanging bottle. The second micropump 8 of two solution hanging bottle Unicoms, the helical catheter tube 9 that is connected with the outlet pipe of the first micropump and the second micropump; Figure 6 In the flow guide tube 13 shown in the fl...

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Abstract

TThe invention discloses a detection apparatus and detection method for drug effect of an anti-cancer drug, i.e., vincristine. According to the invention, the peak value of the signal-to-noise ratio of vincristine with unknown drug effect is compared with the peak value of the signal-to-noise ratio of a frequently used cancer treatment drug, i.e., cisplatin, and the drug effect and dosage of vincristine are obtained in comparison with the known drug effect and dosage of cisplatin. The detection apparatus and detection method provided by the invention have the characteristics of high detection efficiency, good accuracy and capacity of providing reliable bases for safe usage of vincristine so as to ensure safety of patients.

Description

technical field [0001] The invention relates to the technical field of drug efficacy detection, in particular to a drug efficacy detection device and detection method for the anticancer drug vincristine, which can accurately detect the drug efficacy. Background technique [0002] The dosage of anticancer drugs must be accurate, and when the dosage is insufficient, the therapeutic effect will not be achieved. When the dose exceeds the safe dose, it will cause gastrointestinal reactions such as loss of appetite, nausea, vomiting, and diarrhea. The common and serious toxic reaction is nephrotoxic reaction. Repeated medication can aggravate nephrotoxic reaction, mainly damage the proximal convoluted tubule of the kidney, cause cell vacuolation, epithelial shedding, lumen dilation, hyaline casts, and excessive uric acid in the blood. In severe cases, it can cause symptoms such as hematuria. [0003] When used in large doses and repeatedly, neurotoxic reactions will occur, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/28
CPCG01N27/28
Inventor 万海方黄丽霞陶凡
Owner HANGZHOU RED CROSS HOSPITAL