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Application of lactobacillus to preparation of product for preventing and/or treating weight loss caused by alcohol intake

A technology for weight loss and lactic acid bacteria, applied in the field of biomedicine, can solve difficult problems such as treatment

Active Publication Date: 2016-08-24
BEIJING UNIV OF AGRI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the defects of drug treatment are also obvious: drugs are drugs after all, and drugs are three-point poisonous. Drug resistance and side effects are all problems, which will make the treatment more difficult
In the United States, there are no FDA-approved medications that are effective in the treatment of chronic alcohol impairment, particularly weight loss due to alcohol

Method used

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  • Application of lactobacillus to preparation of product for preventing and/or treating weight loss caused by alcohol intake
  • Application of lactobacillus to preparation of product for preventing and/or treating weight loss caused by alcohol intake
  • Application of lactobacillus to preparation of product for preventing and/or treating weight loss caused by alcohol intake

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Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0038] Used to illustrate the application of the lactic acid bacteria provided by the present invention in the prevention and / or treatment of weight loss caused by intake of alcohol

[0039] According to the settings in Table 1, the mice were randomly divided into 9 groups, 15 in each group. After adaptive feeding for 7 days, each group of mice was treated according to the treatment methods in Table 2 below. The mice were weighed every 2 weeks, and the ratio (feed-to-weight ratio) between the weight of the rat food intake and the weight gain of the mice in each group was calculated when the mice were treated for 12 weeks. The results are shown in Table 3. Among them, the weekly body weight change trends of the blank control group, alcohol model group, Zhang-LL low-dose group, Zhang-LL high-dose group and supernatant group are shown in figure 1 , at 12 weeks, see figure 2 .

[0040] Table 1

[0041]

[0042] Table 2

[0043]

[0044] Note: Alcohol refers to 50% etha...

Embodiment 7

[0046] Used to illustrate the application of the lactic acid bacteria provided by the present invention in the prevention and / or treatment of weight loss caused by intake of alcohol

[0047] A group of 15 mice are treated according to the treatment mode of the above test group, the difference is that the test substance is a mixture of lactic acid bacteria thalline material suspended in equal volume of normal saline and honey liquid (water content 20%), wherein , the content of Bifidobacterium animalis is 10 7 cfu / ml, the amount of honey is such that in each milliliter of the perfusion solution, the sum of the weight of honey and the weight of the bacterial substance and the content of the bacterial substance is 10 8 The mass and weight of the bacterial matter in the cfu / ml bacterial liquid are equal. The mice were weighed every 2 weeks, and the ratio (feed-to-weight ratio) between the weight of the mouse food intake and the weight gain of the mice was calculated when the mice...

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Abstract

The invention relates to the field of biological medicines, in particular to an application of lactobacillus to preparation of a product for preventing and / or treating weight loss caused by alcohol intake. According to the application disclosed by the invention, before, after or during alcohol intake, lactobacillus, especially lactobacillus plantarum can be continuously administrated to relieve the condition of weight loss caused by alcohol. In addition, when the lactobacillus and other medicaments that are capable of preventing and / or treating the body damages caused by alcohol are used together, the condition of the weight loss can be improved more effectively.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of lactic acid bacteria in the preparation of products for preventing and / or treating weight loss caused by alcohol intake. Background technique [0002] With the advancement of human science and technology and economic development, the number of people who are addicted to alcohol and abuse alcohol is also expanding, and has developed into an important problem that cannot be ignored at home and abroad, bringing great harm to society and families. The results published by the World Health Assembly ten years ago showed that alcohol had a morbidity rate of 4.01% and a fatality rate of 3.19%, which illustrated the harmful effects of alcohol on the human body with data. Excessive drinking is the number one cause of threats to the health of people in developing countries, and it is also at the forefront in developed countries. As of 2009 statistics, alcohol-induced diseases ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/744A61K45/06A61P39/00A61P3/00A23L33/135
Inventor 金君华张红星卞丽芳谢远红马京升刘慧
Owner BEIJING UNIV OF AGRI
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