Group of colon cancer metastasis related tumor stroma markers and application

A technology of tumor stroma and markers, applied in the biological field, can solve the problems of insufficient specificity of diagnostic molecules and inaccurate early diagnosis
CN105891484AInactive Publication Date: 2016-08-24XIANGYA HOSPITAL CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
XIANGYA HOSPITAL CENT SOUTH UNIV
Publication Date
2016-08-24
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a group of colon cancer metastasis related tumor stroma markers. The group of marks exist in a tumor stroma, and marker expression abnormality is also more obvious along with the development of canceration, wherein one marker Tenascin-C belongs to a novel extracellular matrix marker, generates abnormal expression in the early stage of tumor canceration, and also generates abnormal expression in a metastasis position, wherein the marker for the self secretion of a tumor is relevant to the metastasis capability. The group of markers can be used for preparing medicines and a kit for colon cancer metastasis screening and auxiliary diagnosis.
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Description

Technical field

[0001] The invention belongs to the field of biotechnology, and specifically relates to a group of colon cancer metastasis-related tumor interstitial markers and applications. Background technique

[0002] Colon cancer (CC) is one of the most common malignant tumors in the gastrointestinal tract, and its incidence has increased significantly in recent years. More than one million people are deeply affected by it every year around the world, and most of them are in the middle or late stage when they are discovered, which seriously threatens human health. The occurrence and metastasis of tumors are closely related to the microenvironment of tumor cells. Therefore, screening key proteins from the microenvironment in the process of colon cancer carcinogenesis is of great significance for in-depth understanding of the mechanism of carcinogenesis, finding diagnostic and therapeutic targets, and preventing tumorigenesis.

[0003] At present, the diagnosis and treatment o...

Claims

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