Targeting drug carrier and preparation method and application thereof

Abstract

The invention provides a targeting drug carrier and a preparation method and an application thereof. The targeting drug carrier is obtained by in vitro cultivating and crushing a primary tumour cell and coating the product with taken homologous tumor cell membrane. The invention further provides a pharmaceutical purpose of the targeting drug carrier. Drug molecules of DNA, RNA, polypeptide and the like are loaded by the targeting drug carrier through an electrostatic adsorption or covalent coupling method; the prepared targeting drug preparation is capable of attacking the cancer cell in a body of a patient at high specificity, is free of a killing effect on normal cells, and is an efficient targeting tumor drug. By the targeting drug carrier, target molecules on the surface of the tumor cell of the patient are identified through the homologous tumor cell membrane, so that the functions of specifically combining nanoparticles with the tumor cell and transmitting the targeting drug to the tumor cell are achieved; and the targeting drug carrier has a wide application prospect in the aspects of early tumor diagnosis, biomedical imaging and targeting medicine treatment.

Description

technical field [0001] The invention relates to a nano drug carrier material for targeted recognition of tumor cells based on homologous tumor cell membranes, a preparation method and application thereof. Background technique [0002] Cancer is a major disease that causes human death, and the number of deaths due to cancer is about 7 million worldwide every year. With the development of cell biology and the understanding of cancer pathogenesis, the drug treatment of cancer has been well developed. At present, there are about a variety of chemical drugs and antibody drugs developed to kill tumor cells and treat cancer. However, these drugs lack target specificity and often bring fatal side effects to patients in clinical practice. At the same time, antibody drugs have achieved good results in in vitro anti-tumor experiments, but once applied in vivo, they will be cleared by the immune system in the human body; and after the drug is modified in vitro, although it can partial...

AI Technical Summary

Problems solved by technology

To be able to individualize the treatment of different cancer patients, it is necessary to screen the cancer cell targets of a single patient, which is extremely expensive and time-consuming, and has no commercial value

Existing targeted tumor drugs generally use specific antibodies to identify tumor cells. There are several problems with specific antibodies: first, some tumors have not yet found specific antibodies, and specific antibodies cannot be used for targeted recognition; Second, due to the heterogeneity of tumors, specific antibodies cannot recognize certain tumor subtypes

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