Acotiamide hydrochloride preparation and application thereof

Abstract

The invention discloses an acotiamide hydrochloride preparation and application thereof. The acotiamide hydrochloride preparation is prepared from acotiamide hydrochloride, lactose, microcrystalline cellulose and a pharmaceutically acceptable carrier. The prepared acotiamide hydrochloride preparation has good mobility, stability and dissolution rate so as to be suitable for industrial mass production. The acotiamide hydrochloride preparation is a pharmaceutical composition treating functional dyspepsia (FD), is reasonable in proportion, can quickly release drugs, and can generate excellent curative effects to diseases.

Description

technical field [0001] The invention relates to the use of acotiamide hydrochloride for preparing medicines, especially for preparing tablets and capsules suitable for oral administration. [0002] Acotiamide hydrochloride (Acotiamide), molecular formula: C21H30N4O5S·HCL·3H2O, molecular weight: 541.06, chemical name: N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2 -Hydroxy-4,5-dimethoxybenzoyl)amino]thiazole-4-carboxamide hydrochloride trihydrate [0003] It is a three-class new drug for the treatment of functional dyspepsia (FD), and is currently undergoing preclinical research. Background technique [0004] Functional dyspepsia (FD) refers to epigastric symptoms such as epigastric pain, epigastric distension, early satiety, belching, loss of appetite, nausea, and vomiting that accumulate for more than 12 weeks within a year, and various objective examinations fail to detect organic diseases . It is a frequently-occurring and common disease worldwide. According to the statist...

AI Technical Summary

Problems solved by technology

[0006] 2. Upper abdominal distension mostly occurs after meals, or is persistently aggravated after meals