Multi-pinhole and single-photon SPECT myocardial blood flow absolute quantification method and application
A technique for absolute quantification of myocardial blood flow, which is applied in applications, diaphragms for radiation diagnosis, and instruments for radiodiagnosis, and can solve problems such as inability to quantify absolutely
Inactive Publication Date: 2016-10-12
刘丽 +2
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[0004] The purpose of the present invention is to provide a technical method for image quantitative reconstruction and myocardial blood flow absolute quantification of multiple pinhole SPECT or SPECT / CT, to overcome the existing multiple pinhole SPECT and SPECT / CT heart imaging technology can only be qualitative Defects that cannot be absolutely quantified and apply this new technology to the assessment of myocardial blood flow status
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[0022] The purpose of the present invention is to provide a technical method for quantitative reconstruction of multi-pinhole SPECT or SPECT / CT images and absolute quantification of myocardial blood flow, and to apply this new technical method to the assessment of myocardial blood flow state. The complete correction step is a necessary condition for obtaining quantitative SPECT images and performing absolute quantification of myocardial blood flow, and the complete correction step can also improve the image quality.
[0023] First, the nuclide physical attenuation correction step: for SPECT or SPECT / CT equipment equipped with multi-pinhole collimators, according to the start time point of dynamic SPECT acquisition, acquisition time length and 99m For the half-life of the Tc nuclide, the exponential decay model is used to calculate the nuclide attenuation correction coefficient at each dynamic time point, so as to recalibrate the radioactive counts that should be in the original...
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The invention relates to a nuclear medicine heart image quantification technology, in particular to to a technological method for multi-pinhole SPECT or SPECT / CT dynamic image quantitative reestablishment and myocardial blood flow absolute quantification measurement and application of the technological method in myocardial blood flow state evaluation. The technological method includes the specific steps of nuclide physical decay correction, in-scanning patient movement correction, scattering correction, geometric warping correction, data truncation compensation, tissue attenuation correction, noise removal, pixel value conversion, myocardial blood flow quantitative calculation and blood flow state evaluation. With the technological means, a quantitative multi-pinhole SPECT dynamic heart image can be generated, myocardial blood flow absolute quantification calculation can be carried out through the quantitative multi-pinhole dynamic image, and thus quantitative measurement of the myocardial blood flow is achieved; meanwhile, a blood flow state diagram is established with the three indexes of resting blood flow, load blood flow and blood flow reserve and is put into the practical application of evaluating the myocardial blood flow state, the purpose of carrying out quantitative measurement of the myocardial blood flow with multi-pinhole SPECT and SPECT / CT dynamic development is achieved, and the technological method can be applied to evaluation of the myocardial blood flow state.
Description
【Technical field】 [0001] The present invention relates to a technical method for quantitative reconstruction of cardiac images in nuclear medicine and absolute quantification of myocardial blood flow, in particular to a multi-pinhole (multi-pinhole) single photon emission computed tomography (single photon emission computed tomography, SPECT) or multi-pinhole single-photon emission computed tomography / X-ray computed tomography (SPECT / CT) dynamic cardiac image processing technology, which can quantify the dynamic images of multi-pinhole single-photon cardiac dynamic imaging in nuclear medicine Reconstruction, and absolute quantitative measurement of myocardial blood flow, and the use of this technique in the assessment of myocardial blood flow. 【Background technique】 [0002] Cardiovascular disease is a common heart disease. According to statistics from the National Health and Family Planning Commission, about 250-300 people per 100,000 people suffer from cardiovascular disea...
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IPC IPC(8): A61B6/03A61B6/06
CPCA61B6/032A61B6/037A61B6/06A61B6/503A61B6/507A61B6/5217A61B6/5235A61B6/5258A61B6/582
Inventor 方纬许百灵刘丽
Owner 刘丽
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