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A method for preparing magnetic vesicles and its application on drug carriers
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A magnetic and vesicle technology, applied in drug delivery, pharmaceutical formulation, liposome delivery, etc., can solve the problems of complex preparation and unknown toxicity of nanoparticles, and achieve the effect of simple method, stable properties and good biocompatibility
Active Publication Date: 2019-04-16
CHINA UNIV OF PETROLEUM (EAST CHINA)
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[0004] At present, the preparation of magnetic vesicles is mainly based on the doping of magnetic nanoparticles. This method is relatively complicated to prepare, and the toxicity of nanoparticles is unknown, and there are potential risks in drug loading.
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[0055] In a preferred embodiment of the present invention, the preparation method of described magnetic surfactant is CTAB and anhydrous FeCl of equimolar ratio 3 Mixed with anhydrous methanol, stirred and reacted for 12 hours; rotary evaporated at 40°C, and then vacuum-dried in a vacuum oven at 45°C for 12 hours to obtain a magnetic surfactant.
[0056] In a preferred embodiment of the present invention, the lipopeptide and the magnetic surfactant are mixed in a mass ratio of 5:1. by attaching image 3 with 4 It can be seen that when the lipopeptide and magnetic surfactant are mixed according to the mass ratio of 5:1, the most vesicles are formed, and the impurities such as fibers are the least. At the same time, the vesicles have better stability over time. When lipopeptide and magnetic surfactant were mixed at a mass ratio of 10:1, more fibers and tubular aggregates appeared, and when lipopeptide and magnetic surfactant were mixed at a mass ratio of 10:3, no obvious aggre...
Embodiment 1
[0059] 1. Preparation of magnetic surfactant:
[0060] Weigh an equimolar ratio of CTAB and anhydrous FeCl 3 (100mM) was placed in a 250mL round bottom flask, and an appropriate amount of anhydrous methanol was added to dissolve it. After covering with a glass stopper, the reaction was stirred for 12 h. The solvent methanol was evaporated at 40° C. using a rotary evaporator to obtain a preliminary crude product. The crude product in the round-bottom flask was transferred to a watch glass and spread evenly, then placed in a vacuum drying oven, and vacuum-dried at 45° C. for 12 h. The magnetic surfactant can be obtained.
[0061] 2. Preparation of magnetic vesicles
[0062] Weigh 10 mg of lipopeptide, the type of lipopeptide used in this implementation is oleic acid linking two serine molecular formulas:
[0063]
[0064]It can be expressed as (OASS) and 2 mg of the above-mentioned synthesized magnetic surfactant sample is placed in an EP tube, and 6 mL of chloroform is ...
Embodiment 2
[0069] The lipid molecule is a compound of oleic acid (OA) and threonine (T), the molecular formula is as follows:
[0070]
[0071] Other steps are as described in Example 1.
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Abstract
The invention relates to the field of novel biological materials, and particularly relates to a method for preparing magnetic vesicae and application of the magnetic vesicae in a drug carrier. The method comprises the following steps: mixing lipopeptide and a magnetic surfactant in chloroform, and performing rotary evaporation until a film occurs; dissolving the film in an HEPES buffer solution, and repeatedly performing freeze thawing from liquid nitrogen to a water bath at 60 DEG C for multiple times; and extruding vesicae to prepare the magnetic vesicae. The magnetic vesicae prepared by the method have stable properties, have a simple method, and have good biocompatibility to realize various functions. Furthermore, the magnetic vesicae can be a magnetism-controlled drug release carrier since the amount of drug release is subjected to oriental control of a magnetic field, and have scientific meaning to human body targeted medicine treatment.
Description
technical field [0001] The invention relates to the field of new biological materials, in particular to a method for preparing magnetic vesicles and its application on drug carriers. Background technique [0002] Many diseases are treated with drugs. In this process, too low drug concentration cannot play a therapeutic role; too high drug concentration will cause side effects and even damage normal tissues and organs. In addition, the therapeutic effect also depends on whether the drug can remain in the affected area for a sufficient time. In order to improve the efficacy of drugs, it is often necessary to increase the drug concentration and the number of administrations, but too much drugs will damage normal tissues and organs. [0003] The vesicle has a strong solubilizing ability, and its double-layer membrane has good firmness and stability. As a drug carrier, it has a wide range of drug delivery routes, and has high drug loading stability, drug solubilization, and dru...
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