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A pharbitis seed polysaccharide preparing method and an antitumor application of pharbitis seed polysaccharides

A technology of petunias and anti-tumor drugs, applied in the field of medicine, can solve problems such as research on anti-cancer activities that have not been seen

Inactive Publication Date: 2016-10-26
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Through literature search, there is no research on anticancer activity in the reports on the polysaccharides of the petuniasia

Method used

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  • A pharbitis seed polysaccharide preparing method and an antitumor application of pharbitis seed polysaccharides
  • A pharbitis seed polysaccharide preparing method and an antitumor application of pharbitis seed polysaccharides
  • A pharbitis seed polysaccharide preparing method and an antitumor application of pharbitis seed polysaccharides

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of Polysaccharide from Petunia chinensis

[0037] Take morning glory seeds and dry them at 60°C, crush them, and pass through a 60-mesh sieve; put the raw materials in an ultrasonic-microwave device, add 50% ethanol solution 10 times the raw material, set the ultrasonic 500W to normal, and the microwave power to 600W, and extract for 2 hours , centrifuge, take the supernatant, concentrate under reduced pressure to obtain a concentrated solution; add 3 times the volume of ethanol at 95% °C to the obtained concentrated solution, let stand at 5 °C for 24 hours, collect the precipitate, wash and dry, to obtain, after UV Detection, its content is 85.8%.

Embodiment 2

[0039] Tablets: 40g of petuniasia polysaccharide, 140g of starch, 20g of chenodeoxycholate, granulated and compressed into 1000 tablets. Dosage: Adults take 1 tablet at a time, 2 times a day.

Embodiment 3

[0041] Capsules: 40g of morning glory polysaccharide, 140g of starch, 20g of chitosan, mix well, and make 1000 capsules. Dosage: Adults take 1 capsule at a time, 2 times a day.

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Abstract

A pharbitis seed polysaccharide preparing method and an antitumor application of pharbitis seed polysaccharides are disclosed. The method includes drying pharbitis seeds at 60 DEG C, crushing, sieving with a sieve having a size of 60 meshes, adding the raw material into an ultrasonic-microwave device, adding an ethanol solution the concentration of which is 40-50% and the mass of which is 8-10 times of the mass of the raw material, setting the power of ultrasonic waves to be 500 W in a normally-on mode, setting the microwave power to be 600-800 W, extracting for 2-3 h, centrifuging to obtain a liquid supernatant, concentrating under vacuum, precipitating with ethanol, filtering, collecting a precipitate, washing and drying. Pharmacodynamic evaluation proves that the high-concentration pharbitis seed polysaccharides have good tumor inhibiting functions. The pharbitis seed polysaccharides and medically acceptable auxiliary materials are prepared into an antitumor medicine. The dosage form of the medicine is one of an injection, a capsule, a tablet, granules, pills, a mixture and an oral liquid.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method and anti-tumor application of petunia polysaccharide. Background technique [0002] Cancer has become a disease that seriously endangers human health and is difficult to cure. Chemotherapy is the main method for treating cancer at present, but there are problems such as large toxic side effects and tolerance of tumor cells caused by multiple drugs in chemical drugs. Polysaccharides, also known as polysaccharides, are the most abundant biopolymers in nature. They have the advantages of high efficiency and low toxicity. Regulation of defense and other processes, anti-tumor, anti-virus and hypoglycemic. [0003] Split-leaf morning glory is an annual twining herbaceous plant of the genus Morning glory in the Angiosperm family Convolvulaceae. Scholars at home and abroad have done a lot of research on the chemical composition of its seeds, the main components...

Claims

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Application Information

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IPC IPC(8): A61K36/39A61P35/00
CPCA61K36/39A61K2236/15A61K2236/333A61K2236/53
Inventor 杨成东
Owner NANJING ZELANG MEDICAL TECH