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Pharmaceutical composition for treating gastric cancer and preparation method thereof

A kind of composition and medicine technology, applied in the field of pharmaceutical composition for treating gastric cancer and its preparation field

Inactive Publication Date: 2016-10-26
TONGHUA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the pharmaceutical preparations for the treatment of gastric cancer, which are composed of the total saponins, total flavonoids and total saponins of vine root, combined with astragalus membranaceus, and the active ingredients of the refined two traditional Chinese medicines.

Method used

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  • Pharmaceutical composition for treating gastric cancer and preparation method thereof
  • Pharmaceutical composition for treating gastric cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of capsules

[0026] 1) Take vine root medicinal material and add ethanol with a mass fraction of 75% to heat and reflux for extraction twice. The amount of ethanol solution used each time is 12 times that of the raw material, and the extraction time is 3 hours, and the ethanol extract is combined. HPD-100 type macroporous adsorption resin was used for enrichment and purification, and the mass fraction of 45% ethanol was 12 times the amount of raw materials used for elution, and the elution rate was 6BV / h. The eluate was concentrated under reduced pressure to a thick paste with a relative density of 1.20-1.25 at 45°C, vacuum-dried at 35-45°C, -0.09mpa-0.10mpa, and pulverized to obtain the total flavonoids extract powder of total saponins of vine root, spare;

[0027] 2) Take Radix Astragali medicinal materials and add 60% ethanol to heat and reflux for extraction three times. The amount of ethanol solution used each time is 10 times the amount of raw materi...

Embodiment 2

[0031] Preparation of granules

[0032] 1) Take the vine pear root medicinal material and add 60% ethanol to heat and reflux for extraction 3 times. By weight, the amount of ethanol solution used each time is 10 times that of the raw material, the extraction time is 3 hours, and the ethanol extract is combined. HPD-100 type macroporous adsorption resin was used for enrichment and purification, and the mass fraction of 50% ethanol was 8 times the amount of raw materials used for elution, and the elution rate was 8BV / h. The eluate was concentrated under reduced pressure to a thick paste with a relative density of 1.20-1.25 at 50°C, vacuum-dried at 45-50°C, -0.09mpa-0.10mpa, and pulverized to obtain the total flavonoids extract powder of total saponins of vine root, spare;

[0033] 2) Take Radix Astragali medicinal materials and add 75% ethanol to heat and reflux for extraction twice. The amount of ethanol solution used each time is 10 times the amount of raw materials by weight...

Embodiment 3

[0037] Tablet preparation

[0038] 1) Take vine root medicinal material and add ethanol with a mass fraction of 50% to heat and reflux for extraction three times. The amount of ethanol solution used each time is 8 times that of the raw material, and the extraction time is 2 hours, and the ethanol extract is combined. HPD-100 type macroporous adsorption resin was used for enrichment and purification, and eluted with 60% ethanol with a mass fraction of 12 times the amount of raw materials, and the elution rate was 10BV / h. Concentrate the eluent under reduced pressure to a thick paste with a relative density of 1.20-1.25 at 50°C, vacuum-dry at 45-48°C, -0.08mpa-0.10mpa, and pulverize to obtain the total flavonoids extract powder of total saponins of vine root, spare;

[0039] 2) Take Radix Astragali medicinal materials and add 50% ethanol to heat and reflux for extraction three times. The amount of ethanol solution used each time is 12 times the amount of raw materials by weight...

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Abstract

The invention discloses a pharmaceutical composition for treating gastric cancer and a preparation method thereof. The pharmaceutical composition is characterized in that the pharmaceutical composition is a composition prepared by taking total saponins of radix actinidiae chinensis, total flavonoids and total saponins of radix astragali seu hedysari as effective components. The preparation method of the pharmaceutical composition is characterized by respectively extracting the two medicine materials by using alcohol, thus obtaining extracts; after drying and smashing the extracts, mixing the dried and smashed extracts in proportion, thus obtaining powder, wherein the obtained powder can be prepared into all kinds of oral solid preparations which are clinically accepted through a traditional Chinese medicine preparation conventional preparation method, and the oral solid preparations comprise capsules, granules, tablets, pills and the like. A traditional Chinese medicine preparation for treating the gastric cancer has no side effects, and is capable of effectively treating the gastric cancer and improving the living quality of a patient suffering from the gastric cancer.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating gastric cancer and a preparation method thereof. Background technique [0002] Gastric cancer is the most common malignant tumor of the digestive system, and its mortality rate ranks first among malignant tumors. There are obvious regional differences in the incidence of gastric cancer. The incidence of gastric cancer in the northwest and eastern coastal areas of my country is significantly higher than that in the south, which is closely related to the eating habits of the above-mentioned areas. on the other hand. The infection rate of Helicobacter pylori in adults in areas with a high incidence of gastric cancer in my country is extremely high. Second, the high incidence of gastric cancer is also related to genetic factors. At present, surgery, drug chemotherapy, radiotherapy, hyperthermia, immunotherapy, traditional Chinese medicine an...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P35/00
CPCA61K36/185A61K36/481A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 滕坤阮洪升张海丰刘雪坤臧皓孙仁爽
Owner TONGHUA NORMAL UNIV