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Pharmaceutical composition of desmopressin acetate, and application of same to biological medicine

A desmopressin and composition technology, applied in the field of biomedicine, can solve the problems such as the related reports of desmopressin acetate and its pharmaceutical composition, etc., and achieve the improvement of pulmonary immune function and pulmonary immune function. , improve the effect of improving the effect

Inactive Publication Date: 2016-11-09
王昌荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between desmopressin acetate and its pharmaceutical composition and lung immune function

Method used

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  • Pharmaceutical composition of desmopressin acetate, and application of same to biological medicine
  • Pharmaceutical composition of desmopressin acetate, and application of same to biological medicine
  • Pharmaceutical composition of desmopressin acetate, and application of same to biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Pulverize Huangteng (3kg), extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and successively use petroleum ether (4L×3 times) ), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) extraction, respectively obtain petroleum ether extract, ethyl acetate extract and n-butanol extract; (b) step (a ) in n-butanol extract with AB-8 type macroporous resin for impurity removal, first elute 8 column volumes with 6% ethanol, then elute 8 column volumes with 70% ethanol, collect 70% eluate, decompress Concentrate to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 50:1 (8 column volumes), 25:1 ( 8 column volumes), 15:1 (8 column volumes) and 5:1 (10 column volumes) dichloromethane-...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] In this example, compound (I), desmopressin acetate, and the combination of desmopressin acetate and compound (I) were studied to improve lung immune function.

[0024] 1. Materials and methods

[0025] 1.1 Reagents

[0026] Desmopressin acetate was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Pentobarbital sodium; RPMI1640 (With L-glutamine; Without sodium bicarbonate), GIBCOBRL company; Mycoplasma-free newborn calf serum (New Born Calf Serum), Hyclone company; Hepes, Sigma company; LDH kit, ACP kit, Nanjing Jiancheng Institute of Bioengineering; Hydrobromoornithine; Indian Ink.

[0027] 1.2 Experimental Instruments

[0028] 752 ultraviolet spectrophotometer, Shanghai Third Analytical Instrument Factory; water-proof electric heating constant temperature incubator, Chongqing Sida Experimental Instrumen...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of desmopressin acetate, and application of the same to biological medicine. The pharmaceutical composition of desmopressin acetate contains desmopressin acetate and a natural product compound (I) with a novel structure. Individual action of desmopressin acetate or the compound (I) enables the phagocytic function of alveolar macrophages and the vitality of AMPhi endoenzyme to be improved and exerts improvement effect on the immune functions of the lung. Combined action of desmopressin acetate and the compound (I) exerts better improvement effect on the immune functions of the lung, so the pharmaceutical composition can be developed into a drug for improving the immune functions of the lung; and the pharmaceutical composition has outstanding substantive features and substantial progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of desmopressin acetate, in particular to a pharmaceutical composition of desmopressin acetate and its application in biomedicine. Background technique [0002] Desmopressin acetate can shorten or normalize the excessive bleeding time during clinical invasive treatment or diagnostic operation, or cause uremia, liver cirrhosis, congenital or drug-induced platelet dysfunction, and unknown etiology The blood phenomenon in patients with prolonged bleeding is under control. This product can be used for the control or prevention of bleeding during minor operations in patients with mild hemophilia A and von Willebrand patients who have a positive response to the test dose. For special cases, it can even be used to treat and prevent patients with moderate illness. [0003] So far, there is no report on the correlation between desmopressin acetate and its pharmaceutical composi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48C07C67/56A61K38/11A61P37/02A61P11/00A61K31/22A61K38/095
CPCA61K38/095A61K31/22C07C67/48C07C67/56C07C69/732A61K2300/00
Inventor 王昌荣
Owner 王昌荣
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